{"id":"W2095655371","doi":"10.4269/ajtmh.2009.09-0204","title":"Statins Fail to Improve Outcome in Experimental Cerebral Malaria and Potentiate Toll-Like Receptor-Mediated Cytokine Production by Murine Macrophages","year":2009,"lang":"en","type":"article","venue":"American Journal of Tropical Medicine and Hygiene","topic":"Malaria Research and Control","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Plasmodium berghei; Cerebral Malaria; Cytokine; Immunology; Parasitemia; Plasmodium falciparum; Tumor necrosis factor alpha; Inflammation; Biology; Malaria; TLR2; Medicine; Toll-like receptor; Pharmacology; TLR4; Immune system; Innate immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005102268,0.0007258754,0.001117063,0.0003088898,0.0002538137,0.0003309144,0.0003216288,0.0004831486,0.0009722558],"category_scores_gemma":[0.000449903,0.0002067879,0.0003882709,0.0001716496,0.0004677949,0.0003315823,0.0002246645,0.001145223,0.0003329507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000240832,"about_ca_system_score_gemma":0.0005829459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005838836,"about_ca_topic_score_gemma":0.001192529,"domain_scores_codex":[0.999781,0.00005741017,0.00002622685,0.00001796612,0.00003912208,0.00007832512],"domain_scores_gemma":[0.9996085,0.00004723977,0.0001148414,0.00005614239,0.00004342752,0.0001298847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02467933,0.00330003,0.002164467,0.0003693742,0.0001339411,0.0005927827,0.0001510066,0.0003916612,0.9451171,0.0002884455,0.0008633974,0.02194846],"study_design_scores_gemma":[0.005006702,0.08389746,0.02940743,0.0001069545,0.0004009275,0.001792976,0.0002682613,0.002242163,0.8695941,0.0004178766,0.006814207,0.00005085646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965852,0.001727153,0.0004823792,0.0003012504,0.00007108803,0.00006976779,0.0002023528,0.00006341378,0.0004972615],"genre_scores_gemma":[0.9947369,0.001893202,0.0007741589,0.0002045159,0.00006420983,0.0001261445,0.0005325313,0.00001765964,0.001650747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117063,"threshold_uncertainty_score":0.003252447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046625900885502,"score_gpt":0.2931024505823001,"score_spread":0.2826361915734451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}