{"id":"W2095670128","doi":"10.1139/v07-111","title":"Characterization of the conformational changes in recombinant human metallothioneins using ESI-MS and molecular modeling","year":2007,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Trace Elements in Health","field":"Nursing","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Metallothionein; Electrospray ionization; Molecular model; Electrospray; Recombinant DNA; Molecular dynamics; Random coil; Domain (mathematical analysis); Mass spectrometry; Binding domain; Crystallography; Computational chemistry; Stereochemistry; Binding site; Chromatography; Biochemistry; Circular dichroism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000203549,0.0002836099,0.0001435792,0.0001053268,0.00008185139,0.0001676659,0.0002519032,0.000195723,0.0005231815],"category_scores_gemma":[0.000347443,0.0001023273,0.0002228991,0.0001606285,0.0001408675,0.0001912345,0.0000945018,0.0002928693,0.0001329605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002707127,"about_ca_system_score_gemma":0.0001124663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004024254,"about_ca_topic_score_gemma":0.0003159874,"domain_scores_codex":[0.9999369,0.00001093241,0.000005185513,0.00001890851,0.00002150619,0.000006459732],"domain_scores_gemma":[0.9998872,0.00004832413,0.00002947472,0.00001226503,0.00001342293,0.000009298571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002247172,0.00003805591,0.001984117,0.00006910034,0.00002524043,0.0001844138,0.00005925987,0.01818782,0.9750234,0.0005332058,0.00006523947,0.003605559],"study_design_scores_gemma":[0.00004177033,0.0002795133,0.008022619,0.00000733226,0.00002946228,0.0003387893,0.00004984581,0.1374041,0.8516225,0.0006068607,0.001576527,0.00002069399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889227,0.0002304211,0.01014142,0.00004113089,0.000003460591,0.00001454545,0.0002612176,0.00007026944,0.0003149053],"genre_scores_gemma":[0.9890473,0.0002589445,0.009652453,0.0000184014,0.000001718381,0.00002585618,0.0006343342,0.0000189158,0.0003420287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005231815,"threshold_uncertainty_score":0.001964152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02412306948443882,"score_gpt":0.271395859306898,"score_spread":0.2472727898224591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}