{"id":"W2095687796","doi":"10.1074/jbc.m109.065615","title":"Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; National Institutes of Health; University of Calgary","keywords":"Ku70; Ku80; Autophosphorylation; DNA-PKcs; DNA; Cell biology; DNA clamp; Non-homologous end joining; DNA repair protein XRCC4; DNA repair; DNA ligase; Biology; Replication protein A; Molecular biology; Chemistry; Protein kinase A; Biochemistry; DNA-binding protein; Kinase; Gene; Nucleotide excision repair; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001244623,0.0002470243,0.0001418672,0.0001204897,0.0002433894,0.0005328559,0.0001971506,0.0002804387,0.001207477],"category_scores_gemma":[0.0002586946,0.0002659746,0.00009857934,0.00008306236,0.0003386501,0.0005408005,0.0002890545,0.0003238345,0.0004951566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005926227,"about_ca_system_score_gemma":0.000253028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002775905,"about_ca_topic_score_gemma":0.0005711657,"domain_scores_codex":[0.9998947,0.00001183921,0.000004390323,0.00003063737,0.00002328018,0.00003508829],"domain_scores_gemma":[0.9999126,0.000008811174,0.00002822592,0.000007766666,0.000009418923,0.00003318618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003445282,0.00003796923,0.001167516,0.0000371742,0.00000754984,0.00005301098,0.00003168952,0.0004144166,0.9933705,0.001215811,0.0001339712,0.003185803],"study_design_scores_gemma":[0.00006338394,0.0002179394,0.0446183,0.00001264889,0.00002079916,0.0004112604,0.0001288092,0.009543488,0.9371938,0.001625797,0.006146085,0.00001779742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944279,0.002383391,0.001636078,0.00009984664,0.00001864667,0.000006710419,0.00005236329,0.00004794552,0.001327111],"genre_scores_gemma":[0.9975343,0.0006041819,0.0005652159,0.00001821356,0.000008021448,0.000006014999,0.00009696762,0.00001352351,0.00115355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001207477,"threshold_uncertainty_score":0.00429976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721392303218613,"score_gpt":0.2664764233501392,"score_spread":0.249262500317953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}