{"id":"W2095687796","doi":"10.1074/jbc.m109.065615","title":"Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; National Institutes of Health; University of Calgary","keywords":"Ku70; Ku80; Autophosphorylation; DNA-PKcs; DNA; Cell biology; DNA clamp; Non-homologous end joining; DNA repair protein XRCC4; DNA repair; DNA ligase; Biology; Replication protein A; Molecular biology; Chemistry; Protein kinase A; Biochemistry; DNA-binding protein; Kinase; Gene; Nucleotide excision repair; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000566467,0.0001740276,0.0002768201,0.0000232922,0.0001501457,0.00006817863,0.000144916,0.0002368355,0.00001642929],"category_scores_gemma":[0.0002026862,0.0001097853,0.00007323542,0.00003824793,0.0002777452,0.00001186768,0.0001319891,0.0002383294,4.626428e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001639559,"about_ca_system_score_gemma":0.00003712005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001171566,"about_ca_topic_score_gemma":6.324344e-7,"domain_scores_codex":[0.999005,0.00006709823,0.0003965783,0.0001985198,0.000124703,0.0002080693],"domain_scores_gemma":[0.9992872,0.00004005076,0.0003342398,0.0001354627,0.00007410075,0.0001288731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002541459,0.00002881327,0.00005754514,0.00001752801,0.00003719973,0.00002784635,0.00004133877,0.000001407737,0.9971696,0.00003935339,0.00002087312,0.002304321],"study_design_scores_gemma":[0.002284164,0.0006232316,0.003503943,0.00005585388,0.00003544282,0.001752883,0.0002921676,0.0003650055,0.989912,0.0008071989,0.000168853,0.0001992142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981655,0.0003782305,0.0002184527,0.0005098593,0.00002704334,0.0001519074,0.00001275449,0.000007639072,0.0005285695],"genre_scores_gemma":[0.9986295,0.000189798,0.0007744075,0.0001850356,0.0001013854,0.000004327294,0.00002376186,0.000006425141,0.00008537543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007257585,"threshold_uncertainty_score":0.4476914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721392303218613,"score_gpt":0.2664764233501392,"score_spread":0.249262500317953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}