{"id":"W2095698720","doi":"10.1111/mmi.12895","title":"Multiple histidines in the periplasmic domain of the <scp><i>S</i></scp><i>almonella enterica</i> sensor kinase <scp>SsrA</scp> enhance signaling in response to extracellular acidification","year":2014,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Periplasmic space; Biology; Histidine kinase; Histidine; Mutant; Cell biology; Extracellular; Biochemistry; Vacuole; Intracellular; Intracellular pH; Response regulator; Amino acid; Gene; Escherichia coli; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002140438,0.0003229222,0.0005017604,0.00006179108,0.0001328178,0.00002526751,0.0009349296,0.000297662,0.000008183689],"category_scores_gemma":[0.002446191,0.0001350396,0.000208995,0.0007042174,0.0002536574,0.00003618274,0.0001806287,0.0003292857,0.00003844517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006012573,"about_ca_system_score_gemma":0.00001633036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001859017,"about_ca_topic_score_gemma":0.0002735669,"domain_scores_codex":[0.9944659,0.003375488,0.0006936539,0.0006881158,0.0001095001,0.0006672752],"domain_scores_gemma":[0.9954074,0.003787899,0.0003158368,0.0003399453,0.00007111012,0.00007779311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004945386,0.0001312836,0.01846048,0.000009580523,0.000008868574,0.00001857091,0.0009416624,0.0001781197,0.9793594,0.00007243766,0.00039094,0.0003791641],"study_design_scores_gemma":[0.000427118,0.0003623309,0.07018755,0.00005755193,0.00001641946,0.00009710431,0.001946404,0.00006589134,0.8112373,0.0002835267,0.1152141,0.0001046907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964685,0.0008093494,0.0002463578,0.001491438,0.0001873775,0.0006287556,0.00004979446,0.00002562451,0.00009284499],"genre_scores_gemma":[0.9973857,0.00002862418,0.000385717,0.001825739,0.00006555733,0.00008220736,0.00006795466,0.000005599888,0.000152928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1681221,"threshold_uncertainty_score":0.5506755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009863792320578223,"score_gpt":0.2114663566812874,"score_spread":0.2016025643607092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}