{"id":"W2095698720","doi":"10.1111/mmi.12895","title":"Multiple histidines in the periplasmic domain of the <scp><i>S</i></scp><i>almonella enterica</i> sensor kinase <scp>SsrA</scp> enhance signaling in response to extracellular acidification","year":2014,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Periplasmic space; Biology; Histidine kinase; Histidine; Mutant; Cell biology; Extracellular; Biochemistry; Vacuole; Intracellular; Intracellular pH; Response regulator; Amino acid; Gene; Escherichia coli; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007315543,0.0002606706,0.0001263946,0.00008669321,0.00009949796,0.0001382748,0.000120937,0.0001480491,0.0008732986],"category_scores_gemma":[0.00008859746,0.00009480399,0.0002583195,0.00007059462,0.0001503961,0.0001383111,0.000196065,0.0003385473,0.0003171083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002941259,"about_ca_system_score_gemma":0.0001702559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005068468,"about_ca_topic_score_gemma":0.0007731807,"domain_scores_codex":[0.9999386,0.00001026398,0.000006548385,0.00001351131,0.00001684174,0.00001423265],"domain_scores_gemma":[0.9998932,0.00001314121,0.00003576108,0.00001005678,0.00001000511,0.00003782108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005845135,0.000006776929,0.0001568923,0.00001022262,0.00000221918,0.00001761994,0.000003381951,0.00002221218,0.9994991,0.00001673484,0.000006230055,0.0002001435],"study_design_scores_gemma":[0.00001282127,0.0002053217,0.009574773,0.000003194876,0.0000120867,0.000259807,0.00002464795,0.0008848573,0.9883987,0.00002954869,0.0005893347,0.00000480118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997972,0.0001010607,0.001398837,0.00003582253,0.000007255765,0.000006419576,0.000117072,0.00003204203,0.0003295784],"genre_scores_gemma":[0.9976852,0.0000704077,0.001378348,0.00002537207,0.000002994632,0.000005098697,0.0002727182,0.00001049429,0.0005494683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008732986,"threshold_uncertainty_score":0.002921462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009863792320578223,"score_gpt":0.2114663566812874,"score_spread":0.2016025643607092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}