{"id":"W2095720502","doi":"10.1097/ccm.0b013e31818024f6","title":"Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism*","year":2008,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"National Center for Complementary and Integrative Health","keywords":"Apocynin; Nicotinamide adenine dinucleotide phosphate; Nitric oxide synthase; Endothelial NOS; Nitric oxide; Internal medicine; Endocrinology; Biopterin; Sepsis; Enos; Oxidase test; NADPH oxidase; Medicine; Biochemistry; Chemistry; Tetrahydrobiopterin; Oxidative stress; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004541492,0.0004327031,0.0004255011,0.0001433179,0.0001076753,0.000205466,0.0002057395,0.0002972559,0.001000508],"category_scores_gemma":[0.0003546025,0.0001701877,0.0002015004,0.0000917108,0.0005346891,0.0002622823,0.000171618,0.0005083035,0.0001347315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000171219,"about_ca_system_score_gemma":0.0003069373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002023842,"about_ca_topic_score_gemma":0.0002949461,"domain_scores_codex":[0.9997426,0.00006005446,0.00002502077,0.00005857128,0.00005713825,0.00005664555],"domain_scores_gemma":[0.9994071,0.00006482025,0.0002876992,0.0000567635,0.000061288,0.0001224284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003634478,0.0002401966,0.002278967,0.0000984029,0.00001435695,0.0001648324,0.00002079376,0.00004338753,0.9913698,0.00005407458,0.00003780894,0.002042835],"study_design_scores_gemma":[0.0003909424,0.02257258,0.09214079,0.00004068134,0.00011768,0.00124051,0.0001202476,0.001402274,0.880918,0.0001226086,0.0009197044,0.00001385999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976084,0.0006836514,0.001373932,0.00004515201,0.00001628159,0.0000364838,0.00007235881,0.00002208554,0.0001416806],"genre_scores_gemma":[0.9969198,0.0007104376,0.001467376,0.00005072317,0.00002038204,0.0001105942,0.0001892759,0.000005543253,0.000525881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001000508,"threshold_uncertainty_score":0.00334698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828833945042552,"score_gpt":0.2746793615287219,"score_spread":0.2563910220782963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}