{"id":"W2095720502","doi":"10.1097/ccm.0b013e31818024f6","title":"Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism*","year":2008,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"National Center for Complementary and Integrative Health","keywords":"Apocynin; Nicotinamide adenine dinucleotide phosphate; Nitric oxide synthase; Endothelial NOS; Nitric oxide; Internal medicine; Endocrinology; Biopterin; Sepsis; Enos; Oxidase test; NADPH oxidase; Medicine; Biochemistry; Chemistry; Tetrahydrobiopterin; Oxidative stress; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009387074,0.001040221,0.002218625,0.0005228893,0.0003904646,0.00002975754,0.0004200419,0.0004311854,0.0006841127],"category_scores_gemma":[0.003917154,0.0008618659,0.0003785442,0.0007641472,0.001328781,0.0004559019,0.0002215045,0.0009082517,0.0000616744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002533851,"about_ca_system_score_gemma":0.000298291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001716007,"about_ca_topic_score_gemma":0.00001108787,"domain_scores_codex":[0.9930584,0.000528472,0.001674164,0.001450005,0.001885901,0.001403023],"domain_scores_gemma":[0.9943541,0.00189718,0.0003376684,0.001282459,0.0007040841,0.001424495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00259063,0.001350681,0.002419846,0.00318106,0.0004022499,0.006402405,0.001161457,0.000009340183,0.9775787,0.0005505651,0.00323125,0.001121798],"study_design_scores_gemma":[0.02292562,0.0067358,0.002323298,0.002326968,0.004616074,0.004745265,0.004727074,0.001106737,0.9480155,0.0007131739,0.0004839212,0.001280598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831686,0.01027112,0.001808789,0.001868817,0.0003037779,0.001435244,0.0004863067,0.0003183733,0.0003389979],"genre_scores_gemma":[0.9859952,0.003105916,0.004784695,0.0044942,0.0006071538,0.0001092349,0.0001838062,0.0002132664,0.0005065397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02956325,"threshold_uncertainty_score":0.9993832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828833945042552,"score_gpt":0.2746793615287219,"score_spread":0.2563910220782963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}