{"id":"W2095773179","doi":"10.1161/circulationaha.110.009480","title":"Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults","year":2011,"lang":"en","type":"review","venue":"Circulation","topic":"Blood properties and coagulation","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; NIHR Cambridge Biomedical Research Centre; Helmholtz Zentrum München; Institute of Genetics; National Health and Medical Research Council; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Cambridge Institute for Medical Research, University of Cambridge; Economic and Social Research Council; Medical Research Council; Directorate for Biological Sciences; National Institutes of Health; National Institute on Aging; National Institute for Health and Care Research; Centre for Cognitive Ageing and Cognitive Epidemiology; ZonMw; University of Glasgow; School of Medicine, Boston University; European Commission; Bristol-Myers Squibb; Royal Society; Bundesministerium für Bildung und Forschung; National Eye Institute; University of Edinburgh; University of Leeds; Münchner Zentrum für Gesundheitswissenschaften; Erasmus Medisch Centrum; Engineering and Physical Sciences Research Council; Cedars-Sinai Medical Center; Age UK; British Heart Foundation; Scottish Government; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Fondation Leducq; King's College London; Juvenile Diabetes Research Foundation International; Universität Ulm; Erasmus Universiteit Rotterdam; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Biotechnology and Biological Sciences Research Council; Wellcome Trust","keywords":"D-dimer; Genome-wide association study; Medicine; Fibrinogen; Fibrin; Genetic association; Internal medicine; Genetics; Gene; Biology; Immunology; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181434,0.0001896639,0.0008957084,0.0002316641,0.00001643548,0.000003438778,0.00005881519,0.0003058184,0.0001159266],"category_scores_gemma":[0.00003433776,0.000157069,0.0001922331,0.0002728688,0.00002635478,0.00004559,0.00001972296,0.0001770043,0.00002936337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009149116,"about_ca_system_score_gemma":0.000240686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001737668,"about_ca_topic_score_gemma":0.00001283884,"domain_scores_codex":[0.9985794,0.00008749644,0.0007390261,0.0002710841,0.000165262,0.0001577112],"domain_scores_gemma":[0.9991842,0.00002403007,0.0003394778,0.0003145725,0.00007305914,0.00006469504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00007904522,0.00006747073,0.01308956,0.01935779,0.00006618093,0.000002045135,0.0002119566,0.000009865086,0.000001404147,0.00002979683,0.00001799194,0.9670669],"study_design_scores_gemma":[0.001586836,0.0004849615,0.6796563,0.03688645,0.001297666,0.00007015169,0.00001707849,0.0003501211,0.000003180933,0.00005661756,0.2792134,0.0003772634],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01969552,0.9785159,0.00004438364,0.000008453533,0.0002044278,0.001128589,0.000009990714,0.0000233956,0.0003693562],"genre_scores_gemma":[0.2153232,0.7841522,0.0001121675,0.00001814947,0.0001894065,0.00004341691,0.0001005058,0.00003665784,0.00002435672],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9666896,"threshold_uncertainty_score":0.6405088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09290704302989446,"score_gpt":0.3135362090525907,"score_spread":0.2206291660226962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}