{"id":"W2095784433","doi":"10.1111/j.1468-1331.2006.01533.x","title":"Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II‐defined cohort of patients with progressive multiple sclerosis: results of a 24‐month double‐blind placebo‐controlled clinical trial and 5 years of follow‐up treatment","year":2006,"lang":"en","type":"article","venue":"European Journal of Neurology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"GDI Integrated Facility Services (Canada); University of Alberta","funders":"","keywords":"Medicine; Placebo; Internal medicine; Multiple sclerosis; Myelin basic protein; Gastroenterology; Autoantibody; Cohort; Clinical trial; Expanded Disability Status Scale; Immunology; Antibody; Myelin; Pathology; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002093433,0.001863593,0.002638723,0.000490493,0.0005112569,0.0008525118,0.0008042759,0.001594519,0.001843941],"category_scores_gemma":[0.001589422,0.0006003807,0.00109677,0.0004141465,0.0009289834,0.0006997578,0.0003148282,0.0018024,0.0004645865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004335439,"about_ca_system_score_gemma":0.0007069774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006092329,"about_ca_topic_score_gemma":0.0008712735,"domain_scores_codex":[0.9992872,0.0003582084,0.00004995303,0.0001216368,0.00006256158,0.0001204821],"domain_scores_gemma":[0.9987809,0.0002367242,0.0002537201,0.0001132773,0.00009282072,0.0005224794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9349788,0.02512996,0.004661049,0.0002949012,0.0007050493,0.0001549904,0.0001208428,0.0003258501,0.01284822,0.00003420778,0.0003879823,0.02035805],"study_design_scores_gemma":[0.5421692,0.4302456,0.02403752,0.00002538203,0.0005519642,0.0001436885,0.00004544223,0.000543703,0.001550964,0.00005327575,0.0006037959,0.00002939603],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978484,0.001152395,0.0001172819,0.00009463253,0.00007165263,0.0003173266,0.0001301814,0.00002639764,0.0002417727],"genre_scores_gemma":[0.9961185,0.001041454,0.0003364743,0.0002424508,0.0003010215,0.0006958754,0.0004362471,0.000008029245,0.0008199885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002638723,"threshold_uncertainty_score":0.01107126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02983467345766971,"score_gpt":0.2697379374215114,"score_spread":0.2399032639638417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}