{"id":"W2095784433","doi":"10.1111/j.1468-1331.2006.01533.x","title":"Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II‐defined cohort of patients with progressive multiple sclerosis: results of a 24‐month double‐blind placebo‐controlled clinical trial and 5 years of follow‐up treatment","year":2006,"lang":"en","type":"article","venue":"European Journal of Neurology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"GDI Integrated Facility Services (Canada); University of Alberta","funders":"","keywords":"Medicine; Placebo; Internal medicine; Multiple sclerosis; Myelin basic protein; Gastroenterology; Autoantibody; Cohort; Clinical trial; Expanded Disability Status Scale; Immunology; Antibody; Myelin; Pathology; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001359971,0.0002705008,0.001227418,0.0003310072,0.00007581376,0.000008443378,0.0002761409,0.0001371949,0.00001174198],"category_scores_gemma":[0.0004194679,0.0001904105,0.000254662,0.0001365533,0.0006953501,0.000105344,0.00007148551,0.000388193,0.000001164287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000176788,"about_ca_system_score_gemma":0.0001949375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000315896,"about_ca_topic_score_gemma":0.00002620817,"domain_scores_codex":[0.9935326,0.00360976,0.002081632,0.0003374373,0.0001230851,0.000315498],"domain_scores_gemma":[0.9966311,0.0007736585,0.001910922,0.0003601215,0.0002665289,0.00005767846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9319566,0.004992809,0.04108548,0.0000122774,0.0005765584,0.0001646224,0.0004821639,0.00007696349,0.01252156,0.000005516569,0.00002958295,0.008095908],"study_design_scores_gemma":[0.5015355,0.06672254,0.4286708,0.0001809355,0.0003447311,0.00004076885,0.0000358414,0.00001135791,0.002008661,0.000003172613,0.0003066215,0.0001391081],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955479,0.002300049,0.000006269855,0.00007621406,0.0004485124,0.001517497,0.00006432718,0.000008750266,0.00003050236],"genre_scores_gemma":[0.9994287,0.0002773965,0.00007139965,0.00002141461,0.00003985182,0.00001934476,0.00004673809,0.00003794129,0.00005719508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4304211,"threshold_uncertainty_score":0.7764715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02983467345766971,"score_gpt":0.2697379374215114,"score_spread":0.2399032639638417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}