{"id":"W2095819219","doi":"10.1016/j.bmc.2012.01.024","title":"Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Bone health and treatments","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Bisphosphonate; Conjugate; Pharmacology; Bone resorption; Osteoporosis; Agonist; In vivo; Receptor; Endocrinology; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001986638,0.0004474771,0.0004895434,0.0003527869,0.0002498609,0.0003495352,0.0005081495,0.0004261152,0.002597766],"category_scores_gemma":[0.0001093722,0.0002836328,0.000321599,0.0002586014,0.0001754596,0.0003878446,0.0003279268,0.0006578825,0.0007449196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002423618,"about_ca_system_score_gemma":0.0004706545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003155473,"about_ca_topic_score_gemma":0.001185249,"domain_scores_codex":[0.9999301,0.000009432625,0.000006794078,0.0000135046,0.00001384164,0.0000262833],"domain_scores_gemma":[0.9999614,0.000004278441,0.000009410403,0.000002776997,0.000008049927,0.00001399092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008213358,0.0004795408,0.0002083289,0.001301148,0.00005865427,0.0007148395,0.0001382287,0.003506159,0.8969497,0.008420976,0.002040591,0.08536049],"study_design_scores_gemma":[0.0007284516,0.003736499,0.0007271174,0.000102902,0.0001185516,0.0008149158,0.00004946814,0.004938316,0.913249,0.001200623,0.07427171,0.00006244634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7606778,0.06137086,0.1364159,0.00198218,0.001119355,0.00183562,0.002498493,0.0008023327,0.03329759],"genre_scores_gemma":[0.8965234,0.02900272,0.058478,0.0005751771,0.0001101462,0.0004789227,0.001088753,0.00005304905,0.01368977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002597766,"threshold_uncertainty_score":0.008690417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0506129673635527,"score_gpt":0.3049372172492661,"score_spread":0.2543242498857134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}