{"id":"W2095825832","doi":"10.1128/aac.00409-12","title":"Maraviroc and Other HIV-1 Entry Inhibitors Exhibit a Class-Specific Redistribution Effect That Results in Increased Extracellular Viral Load","year":2012,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Maraviroc; Viral load; Viral entry; Infectivity; Enfuvirtide; Efavirenz; Virology; Entry inhibitor; Biology; CCR5 receptor antagonist; Extracellular; Virus; Intracellular; Reverse transcriptase; Raltegravir; Viral replication; Gp41; Immunology; Human immunodeficiency virus (HIV); Chemokine; Biochemistry; Antiretroviral therapy; Antibody; Chemokine receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586683,0.0004559,0.0003904851,0.0003377057,0.0001608303,0.0005389138,0.0001975976,0.0002953165,0.001368701],"category_scores_gemma":[0.0001612851,0.0001430338,0.000392298,0.0001774705,0.000201563,0.0002317949,0.000178521,0.0005262031,0.0003780543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002534493,"about_ca_system_score_gemma":0.0001415355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004444191,"about_ca_topic_score_gemma":0.0005599654,"domain_scores_codex":[0.9997348,0.00004304302,0.00001769635,0.00004610879,0.00008500885,0.0000734252],"domain_scores_gemma":[0.9998775,0.00002776045,0.00004219345,0.00001687576,0.00001428893,0.00002140196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001568934,0.00006218531,0.0003881863,0.00003797424,0.000009890813,0.00003647443,0.000008356484,0.0001236559,0.9939082,0.00009278724,0.00004416071,0.005131314],"study_design_scores_gemma":[0.00004473841,0.00125504,0.009382364,0.000006281951,0.00001449825,0.000436631,0.00001192888,0.0008588272,0.9853559,0.00005833114,0.002566475,0.000008977787],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892977,0.004441593,0.00294765,0.000103511,0.00003330952,0.00006301072,0.0003622996,0.0001315056,0.002619392],"genre_scores_gemma":[0.9943646,0.001022194,0.002694885,0.00007473485,0.00002233889,0.00003383497,0.0003765596,0.0000151148,0.001395748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368701,"threshold_uncertainty_score":0.004578769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273333970199558,"score_gpt":0.242407859208554,"score_spread":0.2296745195065584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}