{"id":"W2095830114","doi":"10.1016/j.bbamem.2013.12.019","title":"Structure–activity relationships of the antimicrobial peptide gramicidin S and its analogs: Aqueous solubility, self-association, conformation, antimicrobial activity and interaction with model lipid membranes","year":2014,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Alberta Heritage Foundation for Medical Research","keywords":"Gramicidin S; Chemistry; Membrane; Gramicidin; Lipid bilayer; Phospholipid; Peptide; Bilayer; Antimicrobial peptides; Solubility; Aqueous solution; Biological membrane; Stereochemistry; POPC; Biophysics; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798266,0.0001587501,0.0001336561,0.0001544178,0.00006232733,0.0001535819,0.0001214186,0.0001862709,0.0007348928],"category_scores_gemma":[0.0003746818,0.00007606032,0.0001425164,0.0001817996,0.0001585018,0.0002164256,0.00009259871,0.0002345568,0.0001045656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001723892,"about_ca_system_score_gemma":0.0001210042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004048667,"about_ca_topic_score_gemma":0.0002436448,"domain_scores_codex":[0.9998864,0.00004237056,0.00001248843,0.00001492674,0.00002433673,0.00001942567],"domain_scores_gemma":[0.9997827,0.00008892724,0.0000517696,0.00001212301,0.00002837735,0.000036085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001461129,0.0001339901,0.0008646544,0.00004073693,0.00001986577,0.00006987839,0.00002862538,0.001017275,0.9920941,0.0001135197,0.0000371457,0.004119007],"study_design_scores_gemma":[0.00006049536,0.00314364,0.004198007,0.000003956151,0.00002958527,0.000211903,0.00002341008,0.002271783,0.9891722,0.00005494357,0.0008231485,0.000006944163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988525,0.0005805413,0.0002376349,0.00001570541,0.000003182129,0.000004377782,0.00004927721,0.000003455609,0.0002532366],"genre_scores_gemma":[0.9990808,0.0002565833,0.0002069557,0.00001250277,0.000003278078,0.000004073165,0.000141911,0.000001391363,0.0002924678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007348928,"threshold_uncertainty_score":0.002458453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009999475209317413,"score_gpt":0.2125878734708391,"score_spread":0.2025883982615217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}