{"id":"W2095836604","doi":"10.1146/annurev.genet.35.102401.090432","title":"Animal Models of Tumor-Suppressor Genes","year":2001,"lang":"en","type":"review","venue":"Annual Review of Genetics","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Suppressor; Biology; Gene; Tumor suppressor gene; Function (biology); Mutant; Genetics; Cancer; Cancer research; Cell biology; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006804505,0.001227258,0.001296894,0.002105225,0.0002853753,0.0007362475,0.00128316,0.001205541,0.0035227],"category_scores_gemma":[0.0003687079,0.0002571908,0.0003913291,0.001399093,0.0006825731,0.0009126611,0.0005235162,0.001539085,0.00415151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005312648,"about_ca_system_score_gemma":0.0004448417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006159997,"about_ca_topic_score_gemma":0.0009880767,"domain_scores_codex":[0.9996736,0.0000655148,0.00003025244,0.00006229696,0.0001464247,0.00002188893],"domain_scores_gemma":[0.9998088,0.0000705135,0.000035041,0.00001789677,0.00004270071,0.00002505328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002000912,0.0002799235,0.0007003605,0.008821222,0.0001239268,0.0015337,0.0001125783,0.00070334,0.09543718,0.01754698,0.06577349,0.8087671],"study_design_scores_gemma":[0.00003060981,0.0001468108,0.0006197175,0.0005783234,0.00008466927,0.004054836,0.00002851247,0.00009790516,0.007615346,0.002828253,0.983891,0.00002402919],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001862683,0.9757504,0.007045842,0.0005913502,0.0005717036,0.00006409778,0.0002080259,0.0002736473,0.01363236],"genre_scores_gemma":[0.005684801,0.9782096,0.006663776,0.0006423387,0.0001749666,0.0001291607,0.0004753867,0.0000318219,0.007988121],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0035227,"threshold_uncertainty_score":0.01178461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05006072363477353,"score_gpt":0.353093891593487,"score_spread":0.3030331679587134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}