{"id":"W2095972686","doi":"10.1128/jvi.01222-13","title":"Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers","year":2013,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; University of California, San Francisco","keywords":"Gp41; Trimer; Immunogen; Epitope; Glycoprotein; Biology; Virology; Viral envelope; Viral entry; Monoclonal antibody; Peptide sequence; Antibody; Virus; Biochemistry; Gene; Genetics; Viral replication; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001676335,0.000102386,0.0003282059,0.0001668043,0.00006003019,0.000006900298,0.0001789748,0.0001714533,0.003139338],"category_scores_gemma":[0.00005807133,0.0000734598,0.0000989964,0.00007336183,0.0001836125,0.0001630915,0.00004144576,0.0002736615,0.0008883215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003218585,"about_ca_system_score_gemma":0.0001026676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005206111,"about_ca_topic_score_gemma":0.000002616288,"domain_scores_codex":[0.9989444,0.0002040229,0.0004377713,0.00009573133,0.00004825778,0.0002698356],"domain_scores_gemma":[0.9992255,0.00005584453,0.0003860299,0.0001184595,0.0001736827,0.00004048826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004529821,0.00007096811,0.006793381,0.00000846675,0.0002577934,0.00001308709,0.0001537556,0.000002745189,0.9807236,0.00005216663,0.001328763,0.0101423],"study_design_scores_gemma":[0.006327232,0.003010286,0.4822131,0.00002774903,0.00007637753,0.0007945341,0.0001248338,0.00001091027,0.4902846,0.0003282304,0.01663658,0.0001656222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976549,0.0004354246,0.0001271074,0.0009602953,0.0004098431,0.0001822719,0.00001716484,0.000005224764,0.0002077377],"genre_scores_gemma":[0.9982689,0.0001109168,0.0001530081,0.00007546488,0.00004498991,0.000006416102,0.0000625358,0.000008337397,0.001269434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.490439,"threshold_uncertainty_score":0.9998896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192576643822031,"score_gpt":0.2386251304451858,"score_spread":0.2266993640069655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}