{"id":"W2095972686","doi":"10.1128/jvi.01222-13","title":"Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers","year":2013,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; University of California, San Francisco","keywords":"Gp41; Trimer; Immunogen; Epitope; Glycoprotein; Biology; Virology; Viral envelope; Viral entry; Monoclonal antibody; Peptide sequence; Antibody; Virus; Biochemistry; Gene; Genetics; Viral replication; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169429,0.0001790374,0.00009142728,0.0001050022,0.0001311052,0.0001722602,0.0002142339,0.0002196836,0.0006362136],"category_scores_gemma":[0.0002505047,0.0001031202,0.0001511364,0.0001017742,0.0001455401,0.0002017365,0.0001026501,0.0003734679,0.0001711926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020926,"about_ca_system_score_gemma":0.0001062572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008077087,"about_ca_topic_score_gemma":0.0008364996,"domain_scores_codex":[0.999934,0.000009227291,0.000005602316,0.00001197521,0.00002579057,0.00001343625],"domain_scores_gemma":[0.9998831,0.00002546087,0.00003435197,0.00001341832,0.00002674102,0.00001703341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003691296,0.00001670814,0.0003191729,0.0000147022,0.000004331335,0.00006474967,0.00002563112,0.0001694887,0.9987891,0.00006294862,0.00002193667,0.000474434],"study_design_scores_gemma":[0.00002243285,0.000591358,0.01823519,0.0000134481,0.00003123168,0.001086677,0.0002025828,0.004410853,0.972925,0.0001492237,0.002320267,0.00001176316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968613,0.0003896729,0.00181667,0.00004246331,0.000006093239,0.00001231261,0.0002020983,0.000008545259,0.0006608613],"genre_scores_gemma":[0.9928316,0.0004830813,0.003684089,0.00007170717,0.00000542135,0.00001326867,0.001584605,0.00001493913,0.001311305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008077087,"threshold_uncertainty_score":0.002128363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192576643822031,"score_gpt":0.2386251304451858,"score_spread":0.2266993640069655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}