{"id":"W2095987780","doi":"10.1161/01.res.0000244014.19589.8e","title":"Tissue-Specific Induction of Intestinal ABCA1 Expression With a Liver X Receptor Agonist Raises Plasma HDL Cholesterol Levels","year":2006,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute","keywords":"ABCA1; Liver X receptor; Endocrinology; Internal medicine; Reverse cholesterol transport; Cholesterol; Agonist; Hypertriglyceridemia; ABCG1; Biology; Receptor; Medicine; Lipoprotein; Nuclear receptor; Triglyceride; Transporter; Transcription factor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001771779,0.0003410378,0.0004628095,0.0002519908,0.0001126768,0.000362816,0.0001290578,0.0003224921,0.002305583],"category_scores_gemma":[0.0001732593,0.0002039502,0.0002465723,0.0002222491,0.0002860386,0.0001998072,0.0002219738,0.00091667,0.0005070703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002505104,"about_ca_system_score_gemma":0.0001829792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003830074,"about_ca_topic_score_gemma":0.0006002666,"domain_scores_codex":[0.9997814,0.00004086353,0.0000215826,0.000040411,0.00004442218,0.0000712375],"domain_scores_gemma":[0.9998642,0.00002237452,0.00004089261,0.00001904565,0.00001117176,0.00004226034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002688678,0.00006744497,0.0001290688,0.00002928496,0.000003851207,0.00003442489,0.000007057278,0.00002735676,0.9980136,0.00007046547,0.00003811346,0.001310411],"study_design_scores_gemma":[0.0001176891,0.001675921,0.002987937,0.000006086785,0.00002702256,0.0002154078,0.0000293232,0.0004806105,0.9927465,0.00004905367,0.001659952,0.000004538551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995713,0.0007789307,0.001483291,0.0001950396,0.00003978943,0.00002954201,0.0002160072,0.0001086654,0.001435821],"genre_scores_gemma":[0.9924774,0.000959853,0.002556601,0.00009591735,0.00002446108,0.00005393489,0.000458609,0.0000326432,0.003340692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002305583,"threshold_uncertainty_score":0.00771302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1089436636228917,"score_gpt":0.3478157946222463,"score_spread":0.2388721309993546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}