{"id":"W2096052152","doi":"10.1101/sqb.2008.73.017","title":"Induced Pluripotency of Mouse and Human Somatic Cells","year":2008,"lang":"en","type":"review","venue":"Cold Spring Harbor Symposia on Quantitative Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Harvard Stem Cell Institute; National Institutes of Health; V Foundation for Cancer Research","keywords":"Reprogramming; Somatic cell; Induced pluripotent stem cell; Biology; Epigenetics; Cell biology; Cell potency; Transcription factor; Embryonic stem cell; Stem cell; Computational biology; Genetics; Cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002714286,0.0006140114,0.001554604,0.0003862543,0.0001586791,0.00001925006,0.000592268,0.0007647236,0.000006658163],"category_scores_gemma":[0.0001450131,0.0005415751,0.0003880915,0.0002081254,0.0004194727,0.000005186548,0.0003809883,0.0004276228,0.00005323209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006005142,"about_ca_system_score_gemma":0.0002701776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004727098,"about_ca_topic_score_gemma":0.000006855424,"domain_scores_codex":[0.9968178,0.0006401857,0.0008336352,0.0009745072,0.0001954619,0.0005384148],"domain_scores_gemma":[0.998076,0.0001974309,0.0006195722,0.000779117,0.0001545475,0.0001733772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003007373,0.0001725547,0.00003707196,0.003538731,0.0004321079,0.00001708992,0.00001691128,7.342422e-7,0.8140512,0.1801894,0.00006234051,0.001451792],"study_design_scores_gemma":[0.0005863284,0.002576657,0.00006004798,0.002248488,0.0001495074,0.000007773794,0.000008161546,0.000005995274,0.09064245,0.000008327513,0.9029604,0.0007458224],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03873663,0.9595497,0.00006709352,0.000009265818,0.000164017,0.001068545,0.0001150025,0.00002291301,0.0002667898],"genre_scores_gemma":[0.00871553,0.9901392,0.0004784842,0.0000201789,0.0000869841,0.0001401131,0.00004988888,0.0001004637,0.0002691366],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9028981,"threshold_uncertainty_score":0.9997036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05177849070621299,"score_gpt":0.3454130926236003,"score_spread":0.2936346019173873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}