{"id":"W2096084311","doi":"10.1128/mcb.01046-07","title":"Single-Stranded DNA Structure and Positional Context of the Target Cytidine Determine the Enzymatic Efficiency of AID","year":2007,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Terry Fox Foundation; Leukemia and Lymphoma Society of Canada; Leukemia and Lymphoma Society","keywords":"Biology; Cytidine deaminase; Activation-induced (cytidine) deaminase; DNA; Cytidine; Nucleotide; Transcription (linguistics); Deamination; Biochemistry; Enzyme; Transcription factor; Molecular biology; Gene; Genetics; Antibody; Somatic hypermutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004027906,0.0002998312,0.0002688753,0.0002073168,0.0001083342,0.0004412209,0.0002043069,0.0002921255,0.001085925],"category_scores_gemma":[0.0005003053,0.0002124925,0.0001142679,0.0001567248,0.0002790526,0.0002041023,0.0001730326,0.0003072757,0.0006705477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002012755,"about_ca_system_score_gemma":0.0001496553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003526566,"about_ca_topic_score_gemma":0.0005311032,"domain_scores_codex":[0.999634,0.0001137499,0.00002424921,0.00006664257,0.00009955012,0.00006185229],"domain_scores_gemma":[0.9995189,0.0002181973,0.00007382087,0.00003589483,0.00006913157,0.00008405464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005756858,0.000008104898,0.0005937415,0.00002549866,0.000003288915,0.0000146827,0.00000739745,0.00009751406,0.9978772,0.00006735683,0.000005751818,0.00124184],"study_design_scores_gemma":[0.00000248204,0.00009079477,0.002229188,0.000002425222,0.000005541803,0.00009037268,0.00001421887,0.0008074249,0.9963055,0.00003058585,0.000419201,0.000002284505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931455,0.001256594,0.00427717,0.00001967822,0.000007591293,0.00001007761,0.0000620774,0.00002449931,0.001196968],"genre_scores_gemma":[0.9963503,0.0003381697,0.002774938,0.000007834089,0.000002480451,0.000005043344,0.0000862422,0.00000938372,0.0004255223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001085925,"threshold_uncertainty_score":0.003632843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005670165491956394,"score_gpt":0.1922552747640132,"score_spread":0.1865851092720568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}