{"id":"W2096137640","doi":"10.1016/j.bbrc.2010.02.013","title":"Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation","year":2010,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"Japan Society for the Promotion of Science; Senri Life Science Foundation; Astellas Foundation for Research on Metabolic Disorders; Kowa Life Science Foundation; Ministry of Education, Culture, Sports, Science and Technology; Life Science Foundation of Japan; Tokyo Biochemical Research Foundation; Uehara Memorial Foundation; Nakatomi Foundation; YOKOYAMA Foundation for Clinical Pharmacology; Naito Foundation; Takeda Science Foundation","keywords":"RANKL; Osteoclast; RANK Ligand; Receptor; Cell biology; Protein tyrosine phosphatase; Multinucleate; Acid phosphatase; Biology; Cellular differentiation; Signal transduction; Activator (genetics); Internal medicine; Chemistry; Biochemistry; Medicine; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002692242,0.0001434275,0.0001366422,0.00006080949,0.0004216829,0.0001174372,0.0006232476,0.0001836646,0.00002537764],"category_scores_gemma":[0.0003967961,0.0001251952,0.00007412768,0.0002011742,0.000881199,0.00001868938,0.000692031,0.0004339991,0.0000252885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007438416,"about_ca_system_score_gemma":0.00006891766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007273695,"about_ca_topic_score_gemma":0.00002939682,"domain_scores_codex":[0.9986262,0.0002071728,0.0001736572,0.0003939932,0.0002696007,0.0003293753],"domain_scores_gemma":[0.9981232,0.0001058941,0.00003810034,0.001108135,0.0002936308,0.0003309849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006526837,0.0003926282,0.0005558741,0.00001319815,0.00001624399,1.6296e-7,0.0000268909,4.20548e-8,0.9906374,0.003814664,0.0008715006,0.003606154],"study_design_scores_gemma":[0.0003445855,0.0001707741,0.03084305,0.00001859343,0.00001788222,0.000002905304,0.00008029503,0.0002070559,0.957278,0.0009723423,0.0098475,0.0002170775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972513,0.0006030692,0.00003134369,0.001033485,0.00004117052,0.0001792842,0.00008105001,0.00002620914,0.0007530661],"genre_scores_gemma":[0.9962428,0.0006125325,0.00155944,0.00006602104,0.0003240015,0.00005708152,0.0008850038,0.00001862967,0.0002345168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03335943,"threshold_uncertainty_score":0.5105314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03622054350047897,"score_gpt":0.3402549607504816,"score_spread":0.3040344172500026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}