{"id":"W2096139566","doi":"10.1158/1078-0432.ccr-08-2383","title":"DNMT3B Expression Might Contribute to CpG Island Methylator Phenotype in Colorectal Cancer","year":2009,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Japan Society for the Promotion of Science; National Cancer Institute; National Institutes of Health; Gary Bennett Family Fund; Entertainment Industry Foundation","keywords":"DNA methylation; MLH1; Microsatellite instability; Biology; CpG site; Cancer research; Methylation; DNMT3B; Colorectal cancer; CDKN2A; Methyltransferase; Genetics; Molecular biology; Oncology; Cancer; Medicine; DNA mismatch repair; Microsatellite; Gene expression; Gene; Allele","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003713308,0.0002972704,0.0002052369,0.0004921749,0.0001665238,0.0002047742,0.0001491442,0.0003153184,0.001447582],"category_scores_gemma":[0.001130878,0.0001778952,0.0001934163,0.0003788238,0.0002741163,0.0001563961,0.0002258854,0.0003202039,0.0001823171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002745261,"about_ca_system_score_gemma":0.0001823179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001407711,"about_ca_topic_score_gemma":0.001383251,"domain_scores_codex":[0.999844,0.0000437312,0.00001569501,0.00004507405,0.00002740685,0.00002403926],"domain_scores_gemma":[0.9992398,0.0001914701,0.0003883351,0.00004699596,0.00004299554,0.00009038267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001001224,0.00003038406,0.9563036,0.00007772638,0.00009179943,0.000195275,0.00004748931,0.0001377668,0.03660683,0.0000468215,0.00005558897,0.005405349],"study_design_scores_gemma":[0.00001753282,0.0001521988,0.9911199,0.000008782387,0.00009088973,0.001089735,0.00002804674,0.0005915146,0.00658595,0.00005902914,0.0002530756,0.000003379196],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985502,0.00087251,0.0002731685,0.00004505894,0.000001485319,0.000004584197,0.0001064727,0.00001039794,0.0001361902],"genre_scores_gemma":[0.9994376,0.0001867571,0.0001917302,0.000008461767,0.000003214743,0.000003800332,0.00008683909,0.000002156102,0.00007932726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447582,"threshold_uncertainty_score":0.004842639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08936718973930444,"score_gpt":0.4964698144373147,"score_spread":0.4071026246980103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}