{"id":"W2096143852","doi":"10.1128/iai.68.3.1156-1163.2000","title":"Synthetic Peptide Immunogens Elicit Polyclonal and Monoclonal Antibodies Specific for Linear Epitopes in the D Motifs of <i>Staphylococcus aureus</i> Fibronectin-Binding Protein, Which Are Composed of Amino Acids That Are Essential for Fibronectin Binding","year":2000,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; North York General Hospital","funders":"Medical Research Council; Medical Research Council Canada; Health Sciences Centre Foundation","keywords":"Immunogen; Polyclonal antibodies; Epitope; Biology; Monoclonal antibody; Antibody; Molecular biology; Staphylococcus aureus; Peptide; Binding site; Epitope mapping; Biochemistry; Bacteria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006529371,0.0003130615,0.0006815161,0.0002838949,0.0004441919,0.00005092471,0.0001665774,0.0001868902,0.00004250785],"category_scores_gemma":[0.0002975641,0.0002620616,0.0002023272,0.000391767,0.000346232,0.0001600029,0.00007030266,0.0003866662,0.000001458773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006773918,"about_ca_system_score_gemma":0.0000624895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000434551,"about_ca_topic_score_gemma":0.0002677354,"domain_scores_codex":[0.9982452,0.0001818125,0.0006007004,0.000350914,0.0002399707,0.0003814099],"domain_scores_gemma":[0.9982153,0.0005709892,0.0004543738,0.0004421755,0.0002561195,0.00006102699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00215684,0.0003709644,0.1410304,0.001116915,0.00013249,0.000002609052,0.0007925427,0.00005188643,0.8528498,0.00003238088,0.000145924,0.001317282],"study_design_scores_gemma":[0.003322511,0.0007742562,0.39852,0.001908376,0.0001416458,0.0000443613,0.002182208,0.0002940381,0.5908386,0.00006583206,0.001570298,0.0003379062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963188,0.0005935355,0.0003526687,0.0002414327,0.0001062537,0.001937726,0.0003066439,0.00003410552,0.0001087959],"genre_scores_gemma":[0.9977566,0.0006445854,0.001155076,0.0000223575,0.00009876317,0.0000810116,0.00007646066,0.00003729175,0.0001278395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2620112,"threshold_uncertainty_score":0.9999831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02435199473186756,"score_gpt":0.2745855209009538,"score_spread":0.2502335261690863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}