{"id":"W2096155110","doi":"10.1006/viro.2000.0190","title":"Interaction between Virion-Bound Host Intercellular Adhesion Molecule-1 and the High-Affinity State of Lymphocyte Function-Associated Antigen-1 on Target Cells Renders R5 and X4 Isolates of Human Immunodeficiency Virus Type 1 More Refractory to Neutralization","year":2000,"lang":"en","type":"article","venue":"Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Biology; Monoclonal antibody; Virus; Neutralization; Virology; Antigen; Antibody; Viral envelope; Intracellular; Lymphocyte function-associated antigen 1; Intercellular adhesion molecule; Cell adhesion; Cell biology; Cell; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003767384,0.000356316,0.0002602701,0.0002464602,0.0003104166,0.0008265128,0.0004542607,0.0004806698,0.002757552],"category_scores_gemma":[0.0004585262,0.0002700028,0.0003234877,0.0001172474,0.0003766228,0.000395877,0.000456285,0.0007581872,0.0005298339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004363762,"about_ca_system_score_gemma":0.0002076834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007531056,"about_ca_topic_score_gemma":0.0007629665,"domain_scores_codex":[0.99957,0.0001488872,0.00002065512,0.0000411882,0.00006383181,0.000155464],"domain_scores_gemma":[0.999657,0.0001624942,0.00005707297,0.00005152471,0.00001688853,0.00005494582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003071639,0.00006708906,0.0008734502,0.00001662883,0.00001518438,0.0001058668,0.00003644439,0.0001556537,0.9965622,0.0007080637,0.00005403368,0.001098134],"study_design_scores_gemma":[0.00009449197,0.001476431,0.02251375,0.00001311673,0.00005460859,0.001548775,0.0002078658,0.002657928,0.9688366,0.0003358118,0.002243939,0.00001665593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980616,0.0002782365,0.0003403204,0.00002969906,0.000009033598,0.00000542058,0.00001795128,0.00001032109,0.001247524],"genre_scores_gemma":[0.9990857,0.00007262397,0.0001731683,0.00002963863,0.000009830695,0.000004604351,0.00007405847,0.000003887375,0.0005463938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002757552,"threshold_uncertainty_score":0.009224892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281603190488703,"score_gpt":0.2549437212906678,"score_spread":0.2421276893857807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}