{"id":"W2096155110","doi":"10.1006/viro.2000.0190","title":"Interaction between Virion-Bound Host Intercellular Adhesion Molecule-1 and the High-Affinity State of Lymphocyte Function-Associated Antigen-1 on Target Cells Renders R5 and X4 Isolates of Human Immunodeficiency Virus Type 1 More Refractory to Neutralization","year":2000,"lang":"en","type":"article","venue":"Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Biology; Monoclonal antibody; Virus; Neutralization; Virology; Antigen; Antibody; Viral envelope; Intracellular; Lymphocyte function-associated antigen 1; Intercellular adhesion molecule; Cell adhesion; Cell biology; Cell; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002868184,0.0001720703,0.0003615083,0.0001823408,0.0002215514,0.0000115842,0.0001121924,0.0001752492,0.0002796064],"category_scores_gemma":[0.00004866857,0.0001275966,0.00004925033,0.0001889735,0.000470653,0.00007551795,0.00005864636,0.0002069142,0.00008263769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006423597,"about_ca_system_score_gemma":0.00003560023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001458521,"about_ca_topic_score_gemma":0.00007974163,"domain_scores_codex":[0.9985173,0.0005352258,0.0003535603,0.0002876554,0.00005033935,0.0002559458],"domain_scores_gemma":[0.9992303,0.0002523204,0.0001799756,0.000223087,0.00008400894,0.00003027318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003090351,0.0002480567,0.001890031,0.0000143063,0.0002895171,0.000003512194,0.001476203,0.00009381043,0.989742,0.00004584768,0.0001049234,0.003001488],"study_design_scores_gemma":[0.006593115,0.007881842,0.2694647,0.00008684336,0.0001546906,0.00001107085,0.0002749714,0.00005674674,0.7131872,0.0003832171,0.001631282,0.0002743045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976499,0.00148194,0.00004568783,0.0001072283,0.0001315946,0.0003145919,0.0001216958,0.00002007294,0.0001272918],"genre_scores_gemma":[0.9976285,0.00168534,0.000006105256,0.00008200212,0.000006592284,0.000009490327,0.0003617912,0.00001451901,0.0002057283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2765547,"threshold_uncertainty_score":0.5203237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281603190488703,"score_gpt":0.2549437212906678,"score_spread":0.2421276893857807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}