{"id":"W2096171994","doi":"10.1172/jci58577","title":"Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":332,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; McMaster University; Canadian Diabetes Association","keywords":"Insulin resistance; Adipose tissue; Endocrinology; Internal medicine; AMPK; Inflammation; Bone marrow; Adipose tissue macrophages; Macrophage; Biology; Insulin; Chemistry; Medicine; Biochemistry; Protein kinase A; Phosphorylation; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002304564,0.0004452055,0.0004120232,0.0005670413,0.0001987934,0.0003806208,0.0002900452,0.0004312141,0.002277986],"category_scores_gemma":[0.0001496895,0.000300171,0.0002426202,0.0002718859,0.0004163149,0.0002130764,0.0002402559,0.001250928,0.0005463372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002141377,"about_ca_system_score_gemma":0.0002796793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003311066,"about_ca_topic_score_gemma":0.0005933305,"domain_scores_codex":[0.9997759,0.00005486585,0.00002515996,0.00003456477,0.00005120302,0.00005819384],"domain_scores_gemma":[0.9997953,0.00002191277,0.00006810212,0.00002503803,0.00001616617,0.00007349213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007399815,0.0002159122,0.0001491854,0.0000360936,0.00000823116,0.00002831082,0.00001482287,0.00008132692,0.9970222,0.000144722,0.00007281038,0.001486336],"study_design_scores_gemma":[0.0001891551,0.001514878,0.003009488,0.00002317373,0.00003777374,0.0002110079,0.00005000778,0.0006695172,0.9918885,0.0001723805,0.002227338,0.000006792957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921313,0.00209798,0.002651614,0.0004645196,0.0000850517,0.00004571415,0.0004965754,0.0002116397,0.001815699],"genre_scores_gemma":[0.9859504,0.002309865,0.003899317,0.0002853872,0.00003327343,0.000114938,0.0007069939,0.0001102156,0.006589688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002277986,"threshold_uncertainty_score":0.007620692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04141721394672844,"score_gpt":0.3166748931433048,"score_spread":0.2752576791965764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}