{"id":"W2096190607","doi":"10.1172/jci41062","title":"N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":245,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"ADAMTS13; Von Willebrand factor; Chemistry; Acetylcysteine; Platelet; Thrombotic thrombocytopenic purpura; Mucin; Pharmacology; Molecular biology; Biochemistry; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002774656,0.0004697207,0.000258075,0.00042908,0.0001259943,0.0002221002,0.0002657459,0.0005823144,0.001137034],"category_scores_gemma":[0.0002218741,0.0002052645,0.0003240563,0.0001371687,0.0002356639,0.0002051338,0.0001276121,0.0006712487,0.0002362421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349758,"about_ca_system_score_gemma":0.0002455893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005822526,"about_ca_topic_score_gemma":0.0006472224,"domain_scores_codex":[0.9997525,0.00007319996,0.00002988518,0.00004322618,0.00005738149,0.00004390748],"domain_scores_gemma":[0.9998447,0.00002060342,0.00004694004,0.00001733013,0.00001833667,0.00005206717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006713733,0.0002425568,0.0001492525,0.00006905285,0.00001955544,0.00006625831,0.00001971166,0.00004811613,0.9958019,0.0001339022,0.000142788,0.002635576],"study_design_scores_gemma":[0.000166583,0.00359098,0.004509519,0.00001598722,0.00006825643,0.0003494811,0.00002322877,0.001058044,0.9854504,0.0001152264,0.004643866,0.000008396521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871824,0.005847291,0.003089233,0.0004951956,0.0001508397,0.00009931075,0.0004946926,0.0002276873,0.00241346],"genre_scores_gemma":[0.9900031,0.002357747,0.002693493,0.0002153617,0.00003648198,0.00009151124,0.0005018086,0.00002740908,0.004073121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137034,"threshold_uncertainty_score":0.00380379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1126297699523004,"score_gpt":0.3568751759196662,"score_spread":0.2442454059673658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}