{"id":"W2096190607","doi":"10.1172/jci41062","title":"N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":245,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"ADAMTS13; Von Willebrand factor; Chemistry; Acetylcysteine; Platelet; Thrombotic thrombocytopenic purpura; Mucin; Pharmacology; Molecular biology; Biochemistry; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009926436,0.00007685008,0.0003421014,0.00004764469,0.00005149851,0.000006711842,0.0001042271,0.0001040074,0.00007405391],"category_scores_gemma":[0.001212951,0.00004978671,0.00005915646,0.00005302345,0.0004625722,0.0001516823,0.00004408646,0.0002371491,0.00000104896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007200627,"about_ca_system_score_gemma":0.00004842768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005414199,"about_ca_topic_score_gemma":0.00004267526,"domain_scores_codex":[0.9983712,0.0005694029,0.0008331908,0.0001002123,0.00004394413,0.00008204163],"domain_scores_gemma":[0.9977829,0.001142181,0.0008778741,0.00008694732,0.00007512481,0.00003491139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004216595,0.0001269934,0.4237658,0.00004495295,0.0001140182,0.000001787717,0.001064544,7.490777e-7,0.5716257,0.0001415991,0.0002564286,0.002435703],"study_design_scores_gemma":[0.001900467,0.0004922891,0.8554907,0.0001546812,0.00004799891,0.00002724921,0.0002020224,0.000005253443,0.1406143,0.0008770003,0.0001347352,0.00005325212],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987124,0.0004706374,0.00000334709,0.000363321,0.0002430562,0.0001277088,0.000007657235,0.000003115157,0.00006874048],"genre_scores_gemma":[0.9997125,0.00006360009,0.00008401276,0.0000422434,0.00004285762,0.000001471785,0.000001052184,0.000004106111,0.00004820664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4317249,"threshold_uncertainty_score":0.2030243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1126297699523004,"score_gpt":0.3568751759196662,"score_spread":0.2442454059673658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}