{"id":"W2096239824","doi":"10.1530/joe-12-0108","title":"Cysteine cathepsin S processes leptin, inactivating its biological activity","year":2012,"lang":"en","type":"article","venue":"Journal of Endocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Leptin; Cathepsin; Endocrinology; Internal medicine; Cathepsin L; Adipose tissue; Cathepsin S; Chemistry; Cysteine; Cathepsin K; Inflammation; Enzyme; Biochemistry; Biology; Medicine; In vitro; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002066366,0.0001175624,0.0002624272,0.0001300336,0.0001118624,0.00001623974,0.0002274284,0.00006677038,0.00008826334],"category_scores_gemma":[0.002537731,0.00008087308,0.00007195683,0.0002228532,0.00009756395,0.0005293574,0.00007902038,0.0002977689,0.00004527639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004419928,"about_ca_system_score_gemma":0.00006204288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002769185,"about_ca_topic_score_gemma":7.149856e-7,"domain_scores_codex":[0.9988008,0.0002055544,0.0002916195,0.0001278722,0.0001781538,0.0003959576],"domain_scores_gemma":[0.9986922,0.0004820807,0.0004745753,0.0001018784,0.0001417756,0.0001075496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000117557,0.0002824309,0.01629209,0.00002374178,0.000007907773,0.0000435323,0.0001730483,0.0000147619,0.9769528,0.001634301,0.000171264,0.004286558],"study_design_scores_gemma":[0.0003744029,0.0003738029,0.04121627,0.00001840322,0.000005722147,0.00141042,0.00004376816,0.000008301337,0.9367138,0.0001516738,0.0195903,0.00009316442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995732,0.0002712485,0.0002429934,0.001102241,0.0003756251,0.00006403288,0.000001557633,0.0000225962,0.00218767],"genre_scores_gemma":[0.9985022,0.0001952939,0.0002792127,0.0002071604,0.0006399034,0.000001564648,1.506797e-7,0.000007382725,0.0001671459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04023903,"threshold_uncertainty_score":0.3297908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08794226853381779,"score_gpt":0.319066227502881,"score_spread":0.2311239589690632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}