{"id":"W2096272285","doi":"10.1038/ncomms5623","title":"Single-molecule force spectroscopy reveals force-enhanced binding of calcium ions by gelsolin","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Force Microscopy Techniques and Applications","field":"Physics and Astronomy","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China; Agency for Science, Technology and Research","keywords":"Gelsolin; Force spectroscopy; Affinities; Biophysics; Calcium-binding protein; Calcium; Chemistry; Plasma protein binding; Actin; Cytoskeleton; Binding protein; EF hand; Actin-binding protein; Binding site; Binding domain; Molecule; Actin cytoskeleton; Biochemistry; Biology; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226472,0.0002106421,0.0001854336,0.0003109121,0.0002434809,0.0002470039,0.0003789542,0.0006051433,0.001068634],"category_scores_gemma":[0.0002314422,0.0001666968,0.0001655434,0.00013583,0.0002858979,0.0002816066,0.0002102887,0.0006605129,0.0002632579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002652614,"about_ca_system_score_gemma":0.00008867361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007829078,"about_ca_topic_score_gemma":0.0009498065,"domain_scores_codex":[0.999894,0.000007805832,0.000003684967,0.00002587443,0.00004441578,0.00002418068],"domain_scores_gemma":[0.999815,0.00008415247,0.00004470089,0.00001112019,0.00002109908,0.00002386424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002796609,0.00001142039,0.0001187346,0.00002150815,0.000002911628,0.00003908599,0.00002146127,0.00004614107,0.9986995,0.0001158049,0.0000895563,0.0008058219],"study_design_scores_gemma":[0.00001254347,0.00005080559,0.003881883,0.000004086482,0.00000515679,0.0001477323,0.00002658203,0.004504364,0.9901191,0.0001391367,0.001097109,0.00001149324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893659,0.001061427,0.006624988,0.0004104295,0.00007737552,0.00001451287,0.0001959936,0.000142848,0.002106387],"genre_scores_gemma":[0.9931492,0.0005102553,0.004650312,0.0001244303,0.00003051761,0.00001648868,0.00008725379,0.00002208001,0.001409333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001068634,"threshold_uncertainty_score":0.003574908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01299135748419347,"score_gpt":0.3161664592290418,"score_spread":0.3031751017448484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}