{"id":"W2096317294","doi":"10.4049/jimmunol.0904145","title":"NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":424,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Canadian Institutes of Health Research; Multiple Sclerosis Society; National Multiple Sclerosis Society","keywords":"Experimental autoimmune encephalomyelitis; NALP3; Astrogliosis; Inflammasome; Immunology; Multiple sclerosis; Pyrin domain; Innate immune system; Caspase 1; Encephalomyelitis; Acquired immune system; Myelin oligodendrocyte glycoprotein; Myelin; CD8; Interleukin 17; Biology; Medicine; Inflammation; Immune system; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001004653,0.00009865403,0.0001597256,0.00004716521,0.0001124672,0.0000100093,0.0003669938,0.0001100603,0.00002007403],"category_scores_gemma":[0.0003986424,0.00005973611,0.00004261093,0.00004882367,0.0003586792,0.000009343592,0.0001112599,0.0003197491,0.000001032867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006001741,"about_ca_system_score_gemma":0.0001235059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001692436,"about_ca_topic_score_gemma":0.000017009,"domain_scores_codex":[0.9989516,0.000249295,0.0004328745,0.00007367428,0.0001083669,0.0001841875],"domain_scores_gemma":[0.9993804,0.0001812015,0.0001756808,0.000182153,0.00006662094,0.00001393473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003965571,0.00006579673,0.0004562411,0.000002615733,0.00004561498,0.000001843979,0.006187714,4.999356e-7,0.9900749,0.00008923817,0.00005325907,0.002625683],"study_design_scores_gemma":[0.0007867338,0.0005016223,0.03398276,0.00001535524,0.00001342876,0.0002744631,0.01456659,0.000004729944,0.945166,0.0001029882,0.004493362,0.00009197309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850566,0.01402133,0.0000316711,0.0004474501,0.0001425613,0.0000627488,0.000002818098,0.000001133023,0.0002336895],"genre_scores_gemma":[0.9990723,0.0003222676,0.0004385722,0.00009199644,0.00003844048,0.000004887554,0.000004754154,0.000007362812,0.00001938667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04490894,"threshold_uncertainty_score":0.2435968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005552694106910372,"score_gpt":0.2559756261178948,"score_spread":0.2504229320109844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}