{"id":"W2096317294","doi":"10.4049/jimmunol.0904145","title":"NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":424,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Canadian Institutes of Health Research; Multiple Sclerosis Society; National Multiple Sclerosis Society","keywords":"Experimental autoimmune encephalomyelitis; NALP3; Astrogliosis; Inflammasome; Immunology; Multiple sclerosis; Pyrin domain; Innate immune system; Caspase 1; Encephalomyelitis; Acquired immune system; Myelin oligodendrocyte glycoprotein; Myelin; CD8; Interleukin 17; Biology; Medicine; Inflammation; Immune system; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002939964,0.0006485296,0.0003977118,0.0003369221,0.0003216876,0.0004483703,0.0002298479,0.0005334378,0.002206663],"category_scores_gemma":[0.0002028972,0.0001074069,0.000442493,0.0003127058,0.0003922404,0.0004099423,0.0003567396,0.0006497604,0.0007742529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003990917,"about_ca_system_score_gemma":0.0004217608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006149287,"about_ca_topic_score_gemma":0.0005630857,"domain_scores_codex":[0.9997808,0.00004257338,0.00002842589,0.00004134587,0.0000645241,0.00004231231],"domain_scores_gemma":[0.9998042,0.00001302391,0.00008459823,0.00001254046,0.00003488928,0.00005075959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001419346,0.0001119977,0.002672883,0.000858752,0.00006624308,0.0008865391,0.0001121339,0.0002577124,0.9514558,0.001059901,0.002249695,0.03884901],"study_design_scores_gemma":[0.0004527874,0.002277755,0.1022274,0.0004768047,0.0004180807,0.008786419,0.0005291814,0.00254668,0.7414703,0.005863699,0.1348511,0.00009972273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7648403,0.1808787,0.02603076,0.003448806,0.0007670075,0.0003304139,0.00400095,0.002286816,0.01741631],"genre_scores_gemma":[0.9514893,0.03034945,0.00864182,0.0007050182,0.0002294765,0.0001518943,0.001202856,0.00009325314,0.007136904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002206663,"threshold_uncertainty_score":0.007381976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005552694106910372,"score_gpt":0.2559756261178948,"score_spread":0.2504229320109844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}