{"id":"W2096349837","doi":"10.1136/ard.2008.101121","title":"Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors","year":2009,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":349,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Bristol-Myers Squibb Canada; Genentech; Abbott Canada; Synarc; GlaxoSmithKline; Biogen; Bristol-Myers Squibb; Amgen Canada; Servier; Amgen","keywords":"Medicine; Abatacept; Methotrexate; Rheumatoid arthritis; Internal medicine; Adverse effect; Placebo; Gastroenterology; Rheumatoid factor; Rituximab; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001679291,0.0004388585,0.001283821,0.0002416313,0.0002446796,0.0004114779,0.0003342289,0.0007079388,0.001465849],"category_scores_gemma":[0.001776699,0.0002498738,0.0005260637,0.0001820456,0.0003686044,0.0004172839,0.0001271792,0.0009368726,0.0004083813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002358975,"about_ca_system_score_gemma":0.0003995396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002004549,"about_ca_topic_score_gemma":0.0004232242,"domain_scores_codex":[0.9993279,0.0003545037,0.00007003683,0.00006673192,0.0001202799,0.00006047579],"domain_scores_gemma":[0.9986194,0.0005067317,0.0003619239,0.00006365882,0.00009851634,0.0003496647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6681492,0.02379666,0.06473818,0.001201849,0.001615601,0.0003676847,0.0001694548,0.001144211,0.05256872,0.00009834999,0.001433263,0.1847169],"study_design_scores_gemma":[0.2843687,0.5700607,0.1337308,0.0001472588,0.0009114222,0.001160962,0.00006235435,0.001910161,0.005017417,0.0001458151,0.002441832,0.00004250876],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915631,0.007060615,0.0002524633,0.0001376985,0.00005938037,0.0001739917,0.0001258191,0.00002002957,0.0006069997],"genre_scores_gemma":[0.9975579,0.0009874954,0.0004219349,0.0002340708,0.0001323349,0.0001534187,0.0001918458,0.000002864218,0.0003181529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679291,"threshold_uncertainty_score":0.008881032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02696491592765335,"score_gpt":0.319446734496995,"score_spread":0.2924818185693416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}