{"id":"W2096399810","doi":"10.1038/nsmb.1448","title":"Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP","year":2008,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute on Aging","keywords":"Biology; Histone acetyltransferase; Acetyltransferase; Histone H3; Histone; Lysine; Histone octamer; Biochemistry; Acetylation; Histone code; Cell biology; Genetics; Nucleosome; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001011812,0.0005354484,0.0006104143,0.0001466596,0.0002186748,0.00001400914,0.0007268882,0.001254561,0.0001122734],"category_scores_gemma":[0.00007686287,0.00047218,0.0003617543,0.0002573156,0.000588372,0.00001129463,0.0001766618,0.0006613022,0.000003043573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004742556,"about_ca_system_score_gemma":0.000172444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009195642,"about_ca_topic_score_gemma":0.00004981076,"domain_scores_codex":[0.9974706,0.0002274449,0.0005604709,0.0009131473,0.0002122038,0.0006161555],"domain_scores_gemma":[0.9983156,0.00001219329,0.0002435404,0.0009144897,0.0002995043,0.0002146957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001855437,0.00002257026,0.002068609,0.00002152077,0.0002484207,0.00005333086,0.0001680498,0.00009203579,0.9939951,0.00212302,0.0002003988,0.000821396],"study_design_scores_gemma":[0.001785621,0.001303395,0.02309141,0.000007781727,0.000124074,0.001284402,0.00007168786,0.0006081891,0.9672703,0.002333802,0.001257266,0.0008620642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934138,0.003975999,0.0007738572,0.0003219749,0.000549186,0.0003274203,0.0004058531,0.00003855681,0.0001933708],"genre_scores_gemma":[0.9912511,0.0001274955,0.005585989,0.001055939,0.0002031825,0.00001255571,0.001579321,0.00006546512,0.000118954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02672479,"threshold_uncertainty_score":0.999773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005391108034089515,"score_gpt":0.2815935883621396,"score_spread":0.2762024803280501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}