{"id":"W2096399810","doi":"10.1038/nsmb.1448","title":"Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP","year":2008,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute on Aging","keywords":"Biology; Histone acetyltransferase; Acetyltransferase; Histone H3; Histone; Lysine; Histone octamer; Biochemistry; Acetylation; Histone code; Cell biology; Genetics; Nucleosome; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000063347,0.000329505,0.0003289441,0.000153058,0.0003035684,0.0004709045,0.0004530734,0.0005532396,0.001495854],"category_scores_gemma":[0.0001614914,0.0001595679,0.0003696467,0.0002363608,0.0002266804,0.0002643356,0.0002847065,0.0005890468,0.001394032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004911836,"about_ca_system_score_gemma":0.000282069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001273045,"about_ca_topic_score_gemma":0.001154726,"domain_scores_codex":[0.9999034,0.00000529805,0.00000703869,0.0000364051,0.0000329713,0.0000148272],"domain_scores_gemma":[0.9998785,0.00001171389,0.00003688393,0.00001698625,0.000009994411,0.0000459309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007271383,0.000007428823,0.0001740877,0.00002510558,0.000004372568,0.0003565855,0.00000644833,0.00004445526,0.9979797,0.0001894573,0.00009261473,0.00104708],"study_design_scores_gemma":[0.00002743224,0.0001194194,0.01167541,0.000006752619,0.00002762231,0.003704205,0.00005080777,0.001668223,0.9745335,0.0002568278,0.007913468,0.00001625122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981135,0.001745224,0.01136404,0.0003512319,0.0001100327,0.00003056715,0.001478111,0.0005639922,0.003221735],"genre_scores_gemma":[0.9873642,0.0004607261,0.004723162,0.00009998682,0.00002478825,0.00001663191,0.003075592,0.00007571134,0.00415916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001495854,"threshold_uncertainty_score":0.005004168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005391108034089515,"score_gpt":0.2815935883621396,"score_spread":0.2762024803280501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}