{"id":"W2096465543","doi":"10.1158/1078-0432.ccr-14-1213","title":"Intratumoral Heterogeneity: From Diversity Comes Resistance","year":2015,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Epigenetics; Cancer; Biology; Cancer research; Disease; Cancer cell; Chemotherapy; Immunology; Medicine; Genetics; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007855371,0.0006835177,0.001580512,0.00200254,0.0002610897,0.001901753,0.00112909,0.001564859,0.002551097],"category_scores_gemma":[0.0008937241,0.0003224546,0.0004733101,0.001322917,0.001212258,0.002414989,0.00103966,0.002312994,0.001635429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001021052,"about_ca_system_score_gemma":0.0009212598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006800341,"about_ca_topic_score_gemma":0.001251856,"domain_scores_codex":[0.9997287,0.00005579344,0.00003148237,0.00005323634,0.00009728878,0.00003344949],"domain_scores_gemma":[0.9995597,0.0002365051,0.00005126395,0.00001793753,0.00009080709,0.00004375235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006266327,0.00003527637,0.0003373152,0.0109076,0.00009107441,0.0004835604,0.0001041422,0.0003591077,0.002091246,0.01199243,0.04124522,0.9322904],"study_design_scores_gemma":[0.000008093162,0.00004353367,0.0005363449,0.002183836,0.00005746669,0.002396513,0.0000853512,0.00006653664,0.0005450676,0.005384452,0.9886741,0.00001871474],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001326158,0.9975336,0.0002070755,0.0008639912,0.0002321189,0.000003978191,0.00001505464,0.000009023938,0.001002669],"genre_scores_gemma":[0.001357144,0.9969722,0.0001396913,0.0005443859,0.0002646498,0.000006741319,0.00002617588,0.000002473488,0.0006865108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002551097,"threshold_uncertainty_score":0.008534312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4433955405684822,"score_gpt":0.5623207732485241,"score_spread":0.1189252326800419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}