{"id":"W2096479500","doi":"10.1016/s1474-4422(14)70191-7","title":"Oral teriflunomide for patients with a first clinical episode suggestive of multiple sclerosis (TOPIC): a randomised, double-blind, placebo-controlled, phase 3 trial","year":2014,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":298,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Ottawa; Ottawa Hospital","funders":"","keywords":"Teriflunomide; Placebo; Multiple sclerosis; Double blind; Medicine; Clinical trial; Physical therapy; Internal medicine; Alternative medicine; Psychiatry; Fingolimod; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002041173,0.000296027,0.002085981,0.0001079037,0.0001996559,0.00001876629,0.0003728016,0.0001697977,0.00003351435],"category_scores_gemma":[0.00677549,0.0001648292,0.000367128,0.0001395134,0.0006996671,0.00005678496,0.0001523266,0.0004869584,0.00001118428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001870168,"about_ca_system_score_gemma":0.00007996988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009674849,"about_ca_topic_score_gemma":0.0004617095,"domain_scores_codex":[0.9968531,0.000716891,0.0008821346,0.0005250712,0.0003603598,0.0006624814],"domain_scores_gemma":[0.9887494,0.009560803,0.0004515516,0.0007219173,0.0003481329,0.000168196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9227421,0.001284943,0.06990122,0.0000764416,0.0004256096,0.000001860654,0.0001087687,0.00002703568,0.0001033519,0.00002948555,0.002188212,0.003111002],"study_design_scores_gemma":[0.9267131,0.01522555,0.0503074,0.00004809086,0.0003231921,0.000002126061,0.000006347905,0.00235516,0.0001156599,0.00002059913,0.004745102,0.0001376509],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807168,0.00003452683,0.0005637443,0.007662113,0.0003650405,0.01031151,0.00008322197,0.00005449017,0.0002085168],"genre_scores_gemma":[0.9942229,0.0001400628,0.0006145149,0.001204501,0.001142312,0.002527371,0.00004331313,0.00004242653,0.00006257211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01959382,"threshold_uncertainty_score":0.8111385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1426383627277224,"score_gpt":0.377089253445585,"score_spread":0.2344508907178627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}