{"id":"W2096532198","doi":"10.1016/j.cllc.2015.01.008","title":"miR Profiling Identifies Cyclin-Dependent Kinase 6 Downregulation as a Potential Mechanism of Acquired Cisplatin Resistance in Non–Small-Cell Lung Carcinoma","year":2015,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Cancer Research Society; Lung Cancer Research Foundation","keywords":"Cyclin-dependent kinase 6; Cisplatin; Cancer research; microRNA; Cell cycle; Cell growth; Kinase; Cyclin-dependent kinase 4; Lung cancer; Downregulation and upregulation; Viability assay; Cell culture; Cyclin-dependent kinase; Medicine; Biology; Cancer; Cyclin-dependent kinase 2; Cell biology; Oncology; Internal medicine; Chemotherapy; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002315851,0.0001243502,0.0002565043,0.0005702494,0.0002417661,0.0005705253,0.0001453259,0.00027291,0.001243292],"category_scores_gemma":[0.0004240664,0.0001668307,0.0001850824,0.0003607487,0.0001728825,0.0002074934,0.0001765349,0.0003045041,0.0003602743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002739263,"about_ca_system_score_gemma":0.0001842588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004088458,"about_ca_topic_score_gemma":0.0006639134,"domain_scores_codex":[0.9998239,0.00002872471,0.00001874182,0.00003490085,0.00006529092,0.00002847905],"domain_scores_gemma":[0.9998596,0.00004052013,0.00003249175,0.00001537173,0.00003241545,0.00001956333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005635374,0.00002954924,0.02311281,0.00005381955,0.00002449662,0.0003536461,0.00005490423,0.0001422179,0.9701445,0.000234128,0.0001732898,0.005113108],"study_design_scores_gemma":[0.00003587595,0.0003900648,0.2351361,0.00001059987,0.0001091379,0.003366798,0.0002191285,0.004980092,0.7501047,0.0002809679,0.005352883,0.00001363389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936658,0.001100485,0.002409276,0.0001120377,0.00001647706,0.00002990886,0.0005079919,0.00006835807,0.002089699],"genre_scores_gemma":[0.9974075,0.0002689117,0.001315722,0.00004251892,0.000005357472,0.00001538546,0.0002886617,0.00001156922,0.0006443072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243292,"threshold_uncertainty_score":0.004159212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963445097942182,"score_gpt":0.3242458020405115,"score_spread":0.3046113510610896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}