{"id":"W2096547558","doi":"10.1186/ar3435","title":"Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts","year":2011,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health","keywords":"SUMO protein; Rheumatology; Scleroderma (fungus); Topoisomerase; Function (biology); DNA; Chemistry; Internal medicine; Medicine; Cancer research; Cell biology; Biology; Biochemistry; Immunology; Ubiquitin; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008549528,0.0001069892,0.0002643547,0.0002638829,0.00006629289,0.00001135464,0.0001368742,0.00007467077,0.0002950018],"category_scores_gemma":[0.00008784981,0.00006532553,0.00007613985,0.0005975313,0.0002690372,0.0001219362,0.00001483023,0.0001954318,0.00001314505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002898695,"about_ca_system_score_gemma":0.0001516516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001294113,"about_ca_topic_score_gemma":0.0001912853,"domain_scores_codex":[0.9980798,0.0003745756,0.0003743048,0.0002165308,0.0006877076,0.0002670995],"domain_scores_gemma":[0.9988471,0.0002049044,0.0001020348,0.0004415037,0.000300593,0.0001039049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01699508,0.003979978,0.1773762,0.0003439414,0.0004885129,0.0001006129,0.02101875,0.00002024894,0.4526895,0.0009328315,0.00263075,0.3234236],"study_design_scores_gemma":[0.009107725,0.003611608,0.9209099,0.003305582,0.00002256519,0.0000538425,0.004082216,0.0001502783,0.05812721,0.0002975941,0.0001983945,0.0001330292],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928612,0.00474973,0.00001834201,0.000179737,0.00003202134,0.0008343621,0.0000103226,0.00001408594,0.00130026],"genre_scores_gemma":[0.9954174,0.004274744,0.00005052539,0.00007192512,0.00004890193,0.00005607792,0.00002979157,0.00001935931,0.00003132234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7435337,"threshold_uncertainty_score":0.3230063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08386177647770653,"score_gpt":0.3055071092645752,"score_spread":0.2216453327868687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}