{"id":"W2096574915","doi":"10.1158/1078-0432.ccr-05-2038","title":"A Phase 1 Clinical Study of Intravenous Administration of PV701, an Oncolytic Virus, Using Two-Step Desensitization","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Ottawa Regional Cancer Foundation; University of Ottawa","funders":"","keywords":"Tolerability; Medicine; Desensitization (medicine); Adverse effect; Oncolytic virus; Regimen; Internal medicine; Dosing; Cohort; Cancer; Gastroenterology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006236507,0.0001585702,0.0004666559,0.0001489882,0.0001256229,0.00002987271,0.0004157615,0.0002661918,0.00006037078],"category_scores_gemma":[0.0006444399,0.0001550179,0.0001396251,0.0005225135,0.0006718283,0.0000120421,0.0001642971,0.0005150923,0.000003861744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000065294,"about_ca_system_score_gemma":0.001659399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001892398,"about_ca_topic_score_gemma":0.01248783,"domain_scores_codex":[0.9941347,0.002518673,0.001391952,0.0006691127,0.0008420234,0.0004435951],"domain_scores_gemma":[0.9972082,0.000313953,0.0002981781,0.0008001957,0.001167403,0.0002120684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03798358,0.02518217,0.02159327,0.00008208511,0.000242901,0.00005040318,0.0001074057,0.001161241,0.8280704,0.00003561955,0.0005036748,0.08498727],"study_design_scores_gemma":[0.0295068,0.2459103,0.01241583,0.0001308757,0.0001609166,0.00001789754,0.001055109,0.01514586,0.6931106,0.0002783557,0.001620314,0.0006471153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978953,0.0003150071,0.0004291775,0.00004687064,0.0001280752,0.0009771897,0.00006154679,0.000008639701,0.0001381843],"genre_scores_gemma":[0.998175,0.0002568176,0.0002801882,0.00003417712,0.0009892177,0.00004232901,0.0001004988,0.00004196925,0.00007984445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2207282,"threshold_uncertainty_score":0.69685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2512174761703061,"score_gpt":0.5851435929750995,"score_spread":0.3339261168047934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}