{"id":"W2096603765","doi":"10.1128/jvi.79.4.2151-2159.2005","title":"Inhibition of Coxsackievirus B3 Replication by Small Interfering RNAs Requires Perfect Sequence Match in the Central Region of the Viral Positive Strand","year":2005,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Louisiana State University; Heart and Stroke Foundation of Canada","keywords":"Small interfering RNA; RNA interference; Biology; Gene knockdown; Viral replication; Gene silencing; Trans-acting siRNA; Virology; RNA; Virus; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006395623,0.00007296105,0.0002422711,0.0001169164,0.00004532157,0.000005470061,0.00013175,0.0001069431,0.00001671215],"category_scores_gemma":[0.0001320717,0.00004212711,0.0001105752,0.0001523803,0.0003029743,0.000123329,0.00003001167,0.0004991351,8.899976e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009411147,"about_ca_system_score_gemma":0.00006907179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001496604,"about_ca_topic_score_gemma":0.00004248792,"domain_scores_codex":[0.9987878,0.0003325551,0.0004880814,0.00009861579,0.000130196,0.0001628113],"domain_scores_gemma":[0.9991487,0.00008459396,0.0003751852,0.0002262811,0.0001425342,0.00002270217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001071025,0.0002265763,0.01152874,0.00001973931,0.00005280757,0.00001579318,0.001117717,0.00004257461,0.9749725,0.0001256687,0.0001402255,0.01068665],"study_design_scores_gemma":[0.002581703,0.00496055,0.4466744,0.0003915615,0.0001091872,0.002981828,0.0006840344,0.000323245,0.5405326,0.0002752845,0.0004066439,0.00007886414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932651,0.0006199578,0.000414917,0.0051612,0.00005895138,0.0001927318,0.000003893326,0.000002079792,0.0002811803],"genre_scores_gemma":[0.9990183,0.0005684418,0.00004365507,0.000257447,0.00007068225,0.000003179055,0.000002346413,0.000005645835,0.00003036398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4351457,"threshold_uncertainty_score":0.2168521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03972657568636182,"score_gpt":0.3232161385785583,"score_spread":0.2834895628921965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}