{"id":"W2096603765","doi":"10.1128/jvi.79.4.2151-2159.2005","title":"Inhibition of Coxsackievirus B3 Replication by Small Interfering RNAs Requires Perfect Sequence Match in the Central Region of the Viral Positive Strand","year":2005,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Louisiana State University; Heart and Stroke Foundation of Canada","keywords":"Small interfering RNA; RNA interference; Biology; Gene knockdown; Viral replication; Gene silencing; Trans-acting siRNA; Virology; RNA; Virus; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003934029,0.0005873512,0.000378681,0.0002152841,0.0002071982,0.0003421723,0.0002257456,0.0003980603,0.0006194725],"category_scores_gemma":[0.000217947,0.0002479011,0.000374297,0.0001511592,0.000275501,0.0001691101,0.000218498,0.0005829172,0.0002920191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003227619,"about_ca_system_score_gemma":0.0003769526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009653742,"about_ca_topic_score_gemma":0.001703365,"domain_scores_codex":[0.9997378,0.00004883897,0.00002966301,0.00005858022,0.0000782194,0.00004695866],"domain_scores_gemma":[0.9998806,0.00004039566,0.00003475635,0.00001509352,0.00001407064,0.00001504712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003911877,0.00001588353,0.000108559,0.00002830439,0.000003782065,0.00001506623,0.00000542372,0.00003685429,0.9989721,0.00004780191,0.00001278948,0.0007143079],"study_design_scores_gemma":[0.00001308886,0.0002580882,0.001726985,0.000004778627,0.00001067275,0.00007699004,0.000008985126,0.000528194,0.9960699,0.00002515396,0.001273479,0.000003667082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804636,0.004631251,0.01201603,0.000139387,0.00006337668,0.0001249052,0.0003041216,0.0001224844,0.002134938],"genre_scores_gemma":[0.9810641,0.002329127,0.01381664,0.00008609789,0.00001397057,0.0001611625,0.0007292658,0.00003318319,0.001766601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009653742,"threshold_uncertainty_score":0.002341807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03972657568636182,"score_gpt":0.3232161385785583,"score_spread":0.2834895628921965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}