{"id":"W2096606886","doi":"10.1038/cdd.2008.29","title":"Bax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage","year":2008,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Région Normandie; Institut National de la Santé et de la Recherche Médicale","keywords":"Transplantation; Small interfering RNA; Apoptosis; Cell biology; Ex vivo; Caspase; Programmed cell death; Biology; Bcl-xL; Ceramide; Caspase 3; Transfection; In vitro; Chemistry; Cell culture; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003698464,0.0001317238,0.0001760261,0.00002837483,0.00005597924,0.000007349561,0.00006530264,0.0001284487,0.000007503166],"category_scores_gemma":[0.00001327705,0.0001131053,0.00005776447,0.00004340289,0.00007430183,0.000008279827,0.00004700134,0.00004612487,5.916033e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002484726,"about_ca_system_score_gemma":0.00001729852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009170818,"about_ca_topic_score_gemma":0.00003437141,"domain_scores_codex":[0.9993056,0.00004341091,0.0002012947,0.0002284559,0.00009108615,0.0001301476],"domain_scores_gemma":[0.9995945,0.00001009253,0.0001275715,0.0001432084,0.00007542912,0.00004918977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009644897,0.0001492419,0.04097129,0.00009678712,0.00002586457,0.000001258765,0.0005226989,0.000002795727,0.9577968,0.00001221789,0.0001787863,0.0001457696],"study_design_scores_gemma":[0.0006961006,0.0003958519,0.06091814,0.00001360335,0.00004669777,0.000004308605,0.0001181435,0.00008091737,0.9374107,0.00008019493,0.0001144888,0.0001209241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968788,0.001427874,0.0006443883,0.00001003008,0.00006303153,0.0001550429,0.00003543725,0.000005653888,0.0007797204],"genre_scores_gemma":[0.997186,0.001849408,0.0002721604,0.00001326624,0.00003512656,0.000005722377,0.0002179473,0.000009415277,0.0004109247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02038621,"threshold_uncertainty_score":0.4612301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441325681752737,"score_gpt":0.2181231651326347,"score_spread":0.2037099083151074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}