{"id":"W2096615679","doi":"10.1016/s1470-2045(11)70406-5","title":"Phase 2 trial design in neuro-oncology revisited: a report from the RANO group","year":2012,"lang":"en","type":"review","venue":"The Lancet Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; Western University","funders":"","keywords":"Medicine; Bevacizumab; Clinical trial; Temozolomide; Clinical study design; Discontinuation; Oncology; Population; Glioma; Drug development; Medical physics; Internal medicine; Intensive care medicine; Drug; Pharmacology; Chemotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.03401858,0.001285197,0.006410226,0.0005617876,0.0003238141,0.002793635,0.001706974,0.002821809,0.00434251],"category_scores_gemma":[0.04226941,0.0004891934,0.005135741,0.001129166,0.0008000386,0.00188187,0.0008968894,0.006633218,0.0008123484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002209995,"about_ca_system_score_gemma":0.003708745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00144221,"about_ca_topic_score_gemma":0.003727266,"domain_scores_codex":[0.987911,0.009589608,0.0007441289,0.0007100023,0.0007967498,0.000248483],"domain_scores_gemma":[0.9684446,0.02618551,0.002100385,0.001096194,0.001611264,0.0005620741],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.1420427,0.001088476,0.002467581,0.03834567,0.01971613,0.0002679059,0.0005018964,0.003153306,0.002805804,0.008167493,0.06240851,0.7190346],"study_design_scores_gemma":[0.3942533,0.04057659,0.01505526,0.03782786,0.06159271,0.001473672,0.000423829,0.005955295,0.00495732,0.02122943,0.4161873,0.0004673885],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03889878,0.8936708,0.01269305,0.02858871,0.009503644,0.004867044,0.003331105,0.0002899032,0.008156916],"genre_scores_gemma":[0.2991757,0.5457602,0.04729168,0.06850715,0.005174007,0.01783823,0.003788888,0.0005966973,0.01186748],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9659814,"threshold_uncertainty_score":0.1799096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2338715737795336,"score_gpt":0.450051414387947,"score_spread":0.2161798406084134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}