{"id":"W2096619102","doi":"10.1016/j.biomaterials.2008.09.025","title":"Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery","year":2008,"lang":"en","type":"article","venue":"Biomaterials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Nanocarriers; Ethylene oxide; Small interfering RNA; Micelle; Polyester; Materials science; Amphiphile; Spermine; Chemistry; Copolymer; Biophysics; Polymer; Polymer chemistry; Drug delivery; Transfection; Biochemistry; Organic chemistry; Nanotechnology; Aqueous solution; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002780864,0.0003093486,0.0002035913,0.000149614,0.0001256828,0.0003162008,0.0002126989,0.0003604348,0.0005735499],"category_scores_gemma":[0.0002554742,0.0002134876,0.0001780126,0.0001251288,0.0001849346,0.0004259317,0.000258474,0.0003513262,0.0003588446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002381474,"about_ca_system_score_gemma":0.0001700581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002677622,"about_ca_topic_score_gemma":0.0006058161,"domain_scores_codex":[0.999862,0.00002365141,0.00001855862,0.00002860039,0.00003560683,0.00003159588],"domain_scores_gemma":[0.9998531,0.0000308719,0.00005290844,0.00001157486,0.00002091621,0.00003064676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005882937,0.00001427409,0.00004383341,0.00003661503,0.000004530269,0.00003172474,0.00001673525,0.000173802,0.9974476,0.0001241418,0.0000322641,0.002015607],"study_design_scores_gemma":[0.00001415628,0.00009519736,0.0004224432,0.000003076929,0.00001018936,0.00005296682,0.000006280437,0.001203123,0.9969086,0.00002995523,0.001247485,0.000006457062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773495,0.002651201,0.01719563,0.0000976833,0.00007817391,0.00007765616,0.0001164805,0.0002424462,0.002191287],"genre_scores_gemma":[0.9894764,0.0007450824,0.007258357,0.00005433757,0.00001325011,0.00005843073,0.00006739738,0.00003503733,0.002291697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005735499,"threshold_uncertainty_score":0.001918674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291904254891165,"score_gpt":0.2295494961357863,"score_spread":0.2166304535868746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}