{"id":"W2096619102","doi":"10.1016/j.biomaterials.2008.09.025","title":"Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery","year":2008,"lang":"en","type":"article","venue":"Biomaterials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Nanocarriers; Ethylene oxide; Small interfering RNA; Micelle; Polyester; Materials science; Amphiphile; Spermine; Chemistry; Copolymer; Biophysics; Polymer; Polymer chemistry; Drug delivery; Transfection; Biochemistry; Organic chemistry; Nanotechnology; Aqueous solution; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001793754,0.0004234505,0.000397313,0.0001449901,0.0002667161,0.0000698256,0.0003625782,0.0002666782,0.00002523721],"category_scores_gemma":[0.00005788415,0.0003502624,0.000192939,0.0001557299,0.000281037,0.00001035882,0.0001108741,0.00001718588,0.00004122908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003100757,"about_ca_system_score_gemma":0.0002000757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004657576,"about_ca_topic_score_gemma":0.0000298027,"domain_scores_codex":[0.9979143,0.0000870115,0.0004295298,0.0007093354,0.0002420564,0.0006177388],"domain_scores_gemma":[0.9988078,0.00002023264,0.0001850163,0.0005948553,0.0001849356,0.0002071287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001046403,0.00009498614,0.0004983342,0.00003625968,0.0001860784,0.00004141039,0.00005988838,0.00002830784,0.9964001,0.00001428694,0.001431033,0.0001629562],"study_design_scores_gemma":[0.001222834,0.00120781,0.0007089612,0.00004293195,0.00006359645,0.0002735751,0.000102315,0.00001954057,0.9893932,0.00001053538,0.006445008,0.0005097425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958345,0.002187829,0.0004313457,0.0001911489,0.0004260705,0.000595308,0.0002130792,0.00006312026,0.00005764544],"genre_scores_gemma":[0.9967702,0.0002477167,0.001062045,0.0005613756,0.0002180392,0.0001406791,0.0003854524,0.0000702549,0.0005442364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007006906,"threshold_uncertainty_score":0.9998949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291904254891165,"score_gpt":0.2295494961357863,"score_spread":0.2166304535868746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}