{"id":"W2096620125","doi":"10.1093/jnci/dju085","title":"Insulin-like Growth Factor Pathway Genetic Polymorphisms, Circulating IGF1 and IGFBP3, and Prostate Cancer Survival","year":2014,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Hellenic Health Foundation; National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; Cancer Research UK","keywords":"IGFBP3; Single-nucleotide polymorphism; Prostate cancer; Hazard ratio; Oncology; Linkage disequilibrium; Internal medicine; SNP; Insulin-like growth factor; Medicine; Proportional hazards model; Cancer; Biology; Confidence interval; Genotype; Genetics; Gene; Growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006539243,0.0002547938,0.0002533986,0.0002429934,0.0001455718,0.0002535156,0.0002064394,0.0002551888,0.001798521],"category_scores_gemma":[0.001930811,0.0001149131,0.0005110978,0.0004422585,0.0001843683,0.000119846,0.0002187068,0.000424886,0.0001236284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002331825,"about_ca_system_score_gemma":0.0003982017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003072713,"about_ca_topic_score_gemma":0.003009061,"domain_scores_codex":[0.9998023,0.0000615379,0.00001256213,0.00005432663,0.00003570068,0.00003362673],"domain_scores_gemma":[0.999135,0.0003302326,0.0002626802,0.00008687689,0.00006351166,0.0001218021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009364984,0.00003409772,0.9918128,0.00001909803,0.0003158248,0.00006574985,0.0000241288,0.001046403,0.001223183,0.00003557437,0.0001322293,0.004354456],"study_design_scores_gemma":[0.00003710666,0.0001393358,0.9956499,0.00000447534,0.000209596,0.0002775999,0.00002012356,0.002988529,0.0003270693,0.0001945999,0.0001460964,0.000005588804],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987484,0.0002456062,0.0006150264,0.00003571125,0.000003359479,0.000003730766,0.0002325095,0.00001045338,0.0001051333],"genre_scores_gemma":[0.9993761,0.00005184402,0.0002777593,0.000008535159,0.000003433558,0.000003850776,0.000180458,0.000001888125,0.00009615259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003072713,"threshold_uncertainty_score":0.006109655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04196163223038378,"score_gpt":0.2915429085772753,"score_spread":0.2495812763468915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}