{"id":"W2096640405","doi":"10.1128/mcb.01002-06","title":"Mammalian Polynucleotide Phosphorylase Is an Intermembrane Space RNase That Maintains Mitochondrial Homeostasis","year":2006,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; American Heart Association; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Muscular Dystrophy Association","keywords":"Polynucleotide phosphorylase; Biology; Purine nucleoside phosphorylase; Cell biology; Intermembrane space; Exoribonuclease; Mitochondrial intermembrane space; Mitochondrion; Inner mitochondrial membrane; Biochemistry; RNase P; RNA; Bacterial outer membrane; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001622104,0.0004025314,0.0003530689,0.0001273907,0.0001680779,0.00005926036,0.0002710747,0.000506096,0.0003443248],"category_scores_gemma":[0.00003761648,0.0003932054,0.000217965,0.0001164364,0.0003209839,0.000009235181,0.0001810221,0.0002032451,0.00005078339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001753613,"about_ca_system_score_gemma":0.000055551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003343498,"about_ca_topic_score_gemma":0.0001599946,"domain_scores_codex":[0.9976898,0.0003358326,0.0003226153,0.0009527014,0.0001176197,0.0005814249],"domain_scores_gemma":[0.99885,0.00001293953,0.0001301024,0.0006947665,0.000067152,0.0002450503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000373798,0.0001214545,0.00124416,0.00001404091,0.00005024043,0.0001429481,0.00005443544,0.000008229144,0.9913697,0.002175665,0.002497334,0.001948057],"study_design_scores_gemma":[0.001337354,0.0007888859,0.0001685653,0.000005359708,0.0000561438,0.0001153036,0.00009727028,0.00002738642,0.8742134,0.0007035424,0.1220442,0.000442608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9565886,0.003402341,0.03630951,0.0006098952,0.0009157814,0.0003341041,0.0001369882,0.00004492585,0.001657841],"genre_scores_gemma":[0.9924573,0.0001434001,0.002128211,0.001645259,0.0006785728,0.00003162242,0.001171971,0.00006358196,0.001680039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1195468,"threshold_uncertainty_score":0.999852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008331883354675187,"score_gpt":0.2229553948451146,"score_spread":0.2146235114904394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}