{"id":"W2096687091","doi":"10.1158/1535-7163.mct-10-0550","title":"Inhibition of Constitutive Activation of STAT3 by Curcurbitacin-I (JSI-124) Sensitized Human B-Leukemia Cells to Apoptosis","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"University of Manitoba; McGill University","keywords":"XIAP; Apoptosis; Gene knockdown; STAT3; Leukemia; Cancer research; Phosphorylation; Chronic lymphocytic leukemia; Cell cycle; Inhibitor of apoptosis; Molecular biology; Chemistry; Programmed cell death; Biology; Cell biology; Immunology; Caspase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001116462,0.0001682529,0.0001988353,0.00006561011,0.00005764487,0.00001023051,0.00008325656,0.0002072552,0.00002510654],"category_scores_gemma":[0.000006489343,0.0001697023,0.00008419221,0.0001384615,0.0001154976,0.000005807593,0.00004573778,0.0001123227,0.000001104009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003626545,"about_ca_system_score_gemma":0.0001174501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001212658,"about_ca_topic_score_gemma":0.00002321025,"domain_scores_codex":[0.9990259,0.00004609792,0.0002829907,0.00027394,0.0001977491,0.0001733471],"domain_scores_gemma":[0.9991764,0.000007394987,0.0002012961,0.0003012011,0.0002513125,0.00006237754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007277593,0.00005592415,0.00003595663,0.00002985331,0.00009950302,3.848381e-7,0.0001351766,0.0004347217,0.995137,0.0007402771,0.0001296819,0.003128782],"study_design_scores_gemma":[0.0006741012,0.0002430192,0.00006976937,0.00003128553,0.00006388255,7.125782e-7,0.00005294651,0.00009360885,0.993485,0.0002310124,0.004867871,0.0001868351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674136,0.0001356787,0.03137877,0.00007211063,0.000189265,0.0003405481,0.0001038053,0.000009206901,0.0003570292],"genre_scores_gemma":[0.9978842,0.00008161803,0.001221122,0.000409935,0.00004614772,0.00002179405,0.0001985648,0.00002770375,0.000108891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03047064,"threshold_uncertainty_score":0.6920258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009510150858963132,"score_gpt":0.262347977439805,"score_spread":0.2528378265808419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}