{"id":"W2096729904","doi":"10.4049/jimmunol.0901474","title":"AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":742,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"","keywords":"Adjuvant; Innate immune system; Cytokine; Immune system; TLR4; Agonist; Immunity; Immunology; Acquired immune system; Biology; Cell biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001984696,0.0005878648,0.0002946592,0.0004223907,0.0001032128,0.000261956,0.0002863046,0.0004357329,0.0009954552],"category_scores_gemma":[0.0001238596,0.0001509828,0.0003603088,0.0001403133,0.0002528794,0.000266211,0.0002603899,0.0003924466,0.0003144631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002231958,"about_ca_system_score_gemma":0.0002971284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001876029,"about_ca_topic_score_gemma":0.000298009,"domain_scores_codex":[0.9998497,0.00004503143,0.00001115166,0.00002461734,0.00003870958,0.00003065545],"domain_scores_gemma":[0.9999222,0.00001302066,0.00002704231,0.000007033173,0.00001036936,0.00002034807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002296772,0.00006623566,0.00008969277,0.00007072184,0.000007745532,0.00001970199,0.000004634963,0.00007075754,0.9971717,0.0000464284,0.00003118161,0.002191612],"study_design_scores_gemma":[0.00005698452,0.003185568,0.0004444032,0.000007219249,0.00002506598,0.000165447,0.00001153701,0.0004692003,0.9928757,0.0000481666,0.002704795,0.000006028044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841083,0.004817396,0.008981826,0.0001283884,0.0001090391,0.0001150353,0.0001937887,0.0001575717,0.001388599],"genre_scores_gemma":[0.9846961,0.002493334,0.009140247,0.0001494499,0.00007060645,0.0001224769,0.0003775301,0.000016794,0.0029334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009954552,"threshold_uncertainty_score":0.003330112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415199173789151,"score_gpt":0.2543335448071418,"score_spread":0.2401815530692503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}