{"id":"W2096729904","doi":"10.4049/jimmunol.0901474","title":"AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":742,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"","keywords":"Adjuvant; Innate immune system; Cytokine; Immune system; TLR4; Agonist; Immunity; Immunology; Acquired immune system; Biology; Cell biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00446699,0.0003679964,0.0009195807,0.0005704284,0.0005860971,0.0000382383,0.0007411247,0.0003996847,0.00005274076],"category_scores_gemma":[0.0004209527,0.0002612173,0.0001788771,0.0003628102,0.0004530702,0.0003374277,0.00006045918,0.001062956,0.00009211974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002280691,"about_ca_system_score_gemma":0.000364697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001159678,"about_ca_topic_score_gemma":0.00001076313,"domain_scores_codex":[0.9929362,0.004883851,0.001243643,0.0002269708,0.0001152249,0.0005940932],"domain_scores_gemma":[0.9972572,0.0007745884,0.0008573579,0.0006201955,0.0004332521,0.000057348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05213118,0.0001620196,0.000001945855,0.00001060342,0.0003249496,0.00002488756,0.00601336,0.0001356799,0.9266062,0.0002540938,0.00005193226,0.01428313],"study_design_scores_gemma":[0.004634661,0.008776953,0.01146675,0.0003646394,0.0002105409,0.001259389,0.006506754,0.00003094014,0.9643828,0.00008077429,0.001953561,0.0003321834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818511,0.01019468,0.004557843,0.002069038,0.0007098451,0.0004431552,0.000007488165,0.00005686199,0.0001100086],"genre_scores_gemma":[0.9989213,0.0002536563,0.0002044728,0.0003513037,0.00003458493,0.000009419376,0.00001324227,0.00002559529,0.0001864299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04749652,"threshold_uncertainty_score":0.999984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415199173789151,"score_gpt":0.2543335448071418,"score_spread":0.2401815530692503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}