{"id":"W2096759707","doi":"10.1074/jbc.m213228200","title":"Targeted Disruption of the ATP2A1 Gene Encoding the Sarco(endo)plasmic Reticulum Ca2+ ATPase Isoform 1 (SERCA1) Impairs Diaphragm Function and Is Lethal in Neonatal Mice","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biology; Gene isoform; Skeletal muscle; Myosin; Diaphragm (acoustics); Mutant; Wild type; Internal medicine; Muscle contraction; Endocrinology; Cell biology; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003810474,0.0008806385,0.0004809535,0.0009575721,0.0003014102,0.0004503158,0.0008064677,0.001023124,0.003169249],"category_scores_gemma":[0.0002341561,0.0005595245,0.0004540771,0.0002240087,0.0006657433,0.0002881921,0.0004053088,0.0008869028,0.00112506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004453699,"about_ca_system_score_gemma":0.0002828829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009237076,"about_ca_topic_score_gemma":0.001303895,"domain_scores_codex":[0.9995851,0.00005010225,0.00006001752,0.0001385538,0.0001106512,0.00005549877],"domain_scores_gemma":[0.9995627,0.0000789402,0.0001570324,0.00002993984,0.00002675467,0.0001445909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001437353,0.00005839683,0.0002300003,0.00006507298,0.00001109089,0.0002560962,0.00003193413,0.0001286772,0.9975018,0.0001839813,0.0001004818,0.001288674],"study_design_scores_gemma":[0.0001527995,0.0008274701,0.01958618,0.00009199067,0.00009242428,0.003171649,0.0001363025,0.002833208,0.9662808,0.0001930215,0.0066079,0.00002623597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851659,0.001986507,0.007665925,0.000181954,0.0001038282,0.00009428745,0.002500964,0.0004171579,0.001883475],"genre_scores_gemma":[0.9715217,0.002674761,0.007105689,0.0001967358,0.00003503209,0.0003025379,0.002757952,0.0002384248,0.01516723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003169249,"threshold_uncertainty_score":0.01060218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03169191299568103,"score_gpt":0.3053492087074763,"score_spread":0.2736572957117953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}