{"id":"W2096774481","doi":"10.1186/s13075-015-0802-3","title":"Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout","year":2015,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; Radboud Universitair Medisch Centrum; Health Research Council of New Zealand; Institute of Genetics; National Institutes of Health; Université Paris Diderot; Canterbury District Health Board; National Center for Research Resources; Radboud Universiteit; Centre Hospitalier Universitaire Vaudois; National Heart, Lung, and Blood Institute; Université de Lausanne; Arthritis New Zealand; Institut National de la Santé et de la Recherche Médicale; University of Otago","keywords":"Gout; Inflammasome; Single-nucleotide polymorphism; Pyrin domain; Medicine; SNP; Internal medicine; Allele; Immunology; Genetics; Genotype; Biology; Inflammation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002793509,0.000854394,0.001119862,0.0008173021,0.0004309404,0.001164928,0.0008949128,0.001000291,0.004108035],"category_scores_gemma":[0.007614059,0.000513619,0.002914026,0.001285136,0.0003995681,0.0004497058,0.000749344,0.0009075181,0.0003035239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002301507,"about_ca_system_score_gemma":0.0004328061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004859689,"about_ca_topic_score_gemma":0.002869684,"domain_scores_codex":[0.9978009,0.0009218134,0.0001514695,0.0007902344,0.0001785424,0.0001570423],"domain_scores_gemma":[0.9962993,0.00218899,0.0004326451,0.0006287075,0.0002143332,0.0002359226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009286703,0.0001117343,0.9281914,0.0006385273,0.03643667,0.0009247824,0.000175406,0.00221539,0.005164298,0.0008929981,0.001156779,0.01480538],"study_design_scores_gemma":[0.0005004763,0.0009833417,0.9461668,0.0001376608,0.03186416,0.001549959,0.0001224596,0.01242523,0.0008369683,0.003499841,0.001870264,0.00004267327],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675044,0.01890127,0.006839613,0.0009261129,0.0003227993,0.00005155851,0.00315211,0.0001933371,0.002108714],"genre_scores_gemma":[0.9965946,0.001046733,0.001080678,0.00009335586,0.00008695535,0.0000347666,0.0005286776,0.00002541535,0.0005087956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004859689,"threshold_uncertainty_score":0.01477367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1015993358586132,"score_gpt":0.3701003409774636,"score_spread":0.2685010051188503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}