{"id":"W2096861611","doi":"10.1128/aac.01855-13","title":"Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure","year":2013,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Merck Canada Inc. (Canada); McGill University Health Centre","funders":"Merck Canada","keywords":"Trypanosoma cruzi; Benznidazole; Parasitemia; Chagas disease; Pharmacology; Biology; Amastigote; Cysteine Proteinase Inhibitors; Microbiology; Biochemistry; Virology; Immunology; Leishmania; Plasmodium falciparum; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002940208,0.0005264445,0.0004009039,0.0003083845,0.000109021,0.0004803007,0.0002928279,0.0005996027,0.003961582],"category_scores_gemma":[0.0001947699,0.0001690827,0.000415849,0.0001490541,0.000281948,0.0004126069,0.0001808997,0.001193591,0.0007958418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002278699,"about_ca_system_score_gemma":0.0001731717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002743131,"about_ca_topic_score_gemma":0.0009334837,"domain_scores_codex":[0.9999158,0.00001527107,0.000004912449,0.00001704568,0.00002710563,0.0000199521],"domain_scores_gemma":[0.9999235,0.00001929815,0.00001891875,0.000006148161,0.00001506878,0.00001713465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001522708,0.0007905872,0.0007806415,0.001220052,0.0001179663,0.0003965744,0.00007870422,0.0007822826,0.7177743,0.004951962,0.005544202,0.2660399],"study_design_scores_gemma":[0.001979433,0.0334859,0.0132807,0.0005526879,0.0005368925,0.003427944,0.0001732298,0.0037644,0.5900474,0.004269373,0.3483376,0.0001445243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4358419,0.4789734,0.02904117,0.008176989,0.00131326,0.0007506164,0.001859924,0.0019922,0.04205053],"genre_scores_gemma":[0.7247424,0.230892,0.01456633,0.002282905,0.0004330429,0.0002370643,0.001798894,0.00009501243,0.02495236],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003961582,"threshold_uncertainty_score":0.01325285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901967505275601,"score_gpt":0.2798706797564023,"score_spread":0.2608510047036462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}