{"id":"W2096891080","doi":"10.1002/syn.20839","title":"Genetic and pharmacological evidence for schizophrenia‐related Disc1 interaction with GSK‐3","year":2010,"lang":"en","type":"article","venue":"Synapse","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Centre for Addiction and Mental Health; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"DISC1; GSK-3; Schizophrenia (object-oriented programming); Genetics; Missense mutation; Glycogen synthase; Prepulse inhibition; Mutation; Biology; Gene; Kinase; Phosphorylation; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559769,0.000839814,0.0003081394,0.0004279322,0.0003232488,0.0003533365,0.0003153831,0.0004918857,0.002050905],"category_scores_gemma":[0.0002137764,0.0002669058,0.0002616761,0.00020816,0.0006772291,0.0001233554,0.000398166,0.0005309484,0.0005071824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005321626,"about_ca_system_score_gemma":0.0002963651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006793293,"about_ca_topic_score_gemma":0.0009505469,"domain_scores_codex":[0.9998147,0.0000320389,0.00001951181,0.00003415102,0.0000655468,0.00003406437],"domain_scores_gemma":[0.9997467,0.00003642065,0.0001242192,0.00002136757,0.000009139341,0.00006214118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001471665,0.00002632752,0.0004541893,0.00005504333,0.0000133402,0.0002441354,0.00000772465,0.00006998852,0.9978189,0.000248079,0.00004367415,0.0008714679],"study_design_scores_gemma":[0.0001183952,0.0004593863,0.02632319,0.00002643787,0.00007410231,0.003188197,0.00003793517,0.001086973,0.9656373,0.0005147818,0.002519939,0.00001330238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890375,0.004378523,0.002668246,0.0005258451,0.00004434978,0.00001576974,0.0004413904,0.0001017838,0.002786655],"genre_scores_gemma":[0.9968109,0.001144649,0.001111848,0.00007711289,0.0000109183,0.00001671876,0.0002482279,0.00001307728,0.0005666121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002050905,"threshold_uncertainty_score":0.006860971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656527363664674,"score_gpt":0.295911642056948,"score_spread":0.2793463684203012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}