{"id":"W2096891080","doi":"10.1002/syn.20839","title":"Genetic and pharmacological evidence for schizophrenia‐related Disc1 interaction with GSK‐3","year":2010,"lang":"en","type":"article","venue":"Synapse","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Centre for Addiction and Mental Health; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"DISC1; GSK-3; Schizophrenia (object-oriented programming); Genetics; Missense mutation; Glycogen synthase; Prepulse inhibition; Mutation; Biology; Gene; Kinase; Phosphorylation; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006703545,0.00008623583,0.00006489587,0.00001887665,0.00007830939,0.00002092901,0.00004425621,0.0001005307,0.00004568818],"category_scores_gemma":[0.00006431837,0.00006086561,0.00002766733,0.00003482081,0.00008564429,0.000007801905,0.0000280993,0.00008874667,0.000004142213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004146888,"about_ca_system_score_gemma":0.00002145202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000424157,"about_ca_topic_score_gemma":0.00003636388,"domain_scores_codex":[0.999514,0.00001956611,0.000097289,0.0002207773,0.00004541161,0.0001029216],"domain_scores_gemma":[0.9997255,0.00002457276,0.00004767848,0.00009803058,0.00004669664,0.00005756698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009285915,0.00003011573,0.003240645,0.000009421954,0.0000407419,0.000001476451,0.00001944786,0.00003260145,0.9904981,0.00006751477,0.0003352074,0.004796127],"study_design_scores_gemma":[0.004777801,0.002354554,0.2152737,0.00007661669,0.0002215314,0.0004185707,0.00009475166,0.002905439,0.7485647,0.0004647361,0.02420874,0.000638919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997286,0.0002128066,0.001577387,0.0002850403,0.0003314569,0.0002229134,0.00000377861,0.00001549629,0.00006512799],"genre_scores_gemma":[0.9979537,0.00007024964,0.001252519,0.0001074175,0.0001429575,0.0000447759,0.00002767184,0.000008896249,0.0003918861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2419334,"threshold_uncertainty_score":0.2482028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656527363664674,"score_gpt":0.295911642056948,"score_spread":0.2793463684203012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}