{"id":"W2096900091","doi":"10.3899/jrheum.090817","title":"Safety, Tolerability, and Clinical Outcomes after Intraarticular Injection of a Recombinant Adeno-associated Vector Containing a Tumor Necrosis Factor Antagonist Gene: Results of a Phase 1/2 Study","year":2009,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tolerability; Adverse effect; Arthritis; Internal medicine; Tumor necrosis factor alpha; Gastroenterology; Placebo; Immunology; Surgery; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003077179,0.00160214,0.001857958,0.0003086716,0.0003253747,0.0007643339,0.0006421176,0.001447164,0.001603637],"category_scores_gemma":[0.001433403,0.0004420107,0.001201207,0.0003228164,0.001199006,0.0007609533,0.0001956309,0.001997108,0.0004999352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004946978,"about_ca_system_score_gemma":0.0007639764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003731153,"about_ca_topic_score_gemma":0.0004542016,"domain_scores_codex":[0.9986518,0.0008066426,0.00007177901,0.0001661321,0.0001689674,0.0001347691],"domain_scores_gemma":[0.9984969,0.0003784719,0.0005570596,0.0001319975,0.0001139822,0.0003214962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7493449,0.08016471,0.01182116,0.0007891472,0.001545004,0.0003705368,0.0002626275,0.001387808,0.09306366,0.00008173563,0.001079727,0.060089],"study_design_scores_gemma":[0.1733481,0.8052438,0.01327546,0.00001891673,0.0004820896,0.0002488155,0.00004033345,0.000598837,0.006229429,0.00003904516,0.0004505699,0.00002463887],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972042,0.0009628208,0.0005361951,0.00008157031,0.00002888174,0.0005316352,0.0002696596,0.00003876513,0.0003462725],"genre_scores_gemma":[0.9947524,0.0009678974,0.001174689,0.0003458461,0.0001708417,0.0009273675,0.0009785262,0.00003026428,0.0006520901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003077179,"threshold_uncertainty_score":0.01627386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311390282409184,"score_gpt":0.3414312504355728,"score_spread":0.318317347611481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}