{"id":"W2096900091","doi":"10.3899/jrheum.090817","title":"Safety, Tolerability, and Clinical Outcomes after Intraarticular Injection of a Recombinant Adeno-associated Vector Containing a Tumor Necrosis Factor Antagonist Gene: Results of a Phase 1/2 Study","year":2009,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tolerability; Adverse effect; Arthritis; Internal medicine; Tumor necrosis factor alpha; Gastroenterology; Placebo; Immunology; Surgery; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002576883,0.0001738753,0.001398276,0.0001721378,0.00009109754,0.00001549902,0.0001584117,0.00009310248,0.00004061205],"category_scores_gemma":[0.002585727,0.0001067168,0.0002276646,0.0001846346,0.0003738519,0.0001068841,0.00005497404,0.0004768379,8.950871e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005558319,"about_ca_system_score_gemma":0.0002036672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003443743,"about_ca_topic_score_gemma":0.0002858428,"domain_scores_codex":[0.9961551,0.0009838437,0.002024077,0.000161472,0.0003874048,0.0002881122],"domain_scores_gemma":[0.997001,0.0009894691,0.001097877,0.0002771395,0.0004632063,0.0001713077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02833792,0.004538169,0.9548198,0.00002977416,0.0008934539,0.00007585881,0.004538872,8.5287e-7,0.001715178,0.00001806304,0.00007734759,0.004954722],"study_design_scores_gemma":[0.02822953,0.02808392,0.9375789,0.0003903932,0.00009965974,0.002808159,0.001657933,0.00008161257,0.0006631771,0.0002649639,0.00003438917,0.000107423],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967637,0.0009310521,0.00003571097,0.001509409,0.0002313651,0.000486156,0.00002522945,0.00001022596,0.00000714458],"genre_scores_gemma":[0.9972762,0.00254277,0.00008774159,0.00006033429,0.000005900748,0.000002835096,0.000002198299,0.0000120181,0.00000996844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02354576,"threshold_uncertainty_score":0.4351783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311390282409184,"score_gpt":0.3414312504355728,"score_spread":0.318317347611481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}