{"id":"W2096908318","doi":"10.1021/bc025504w","title":"Design and Formulation of Polyplexes Based on Pluronic-Polyethyleneimine Conjugates for Gene Transfer","year":2002,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Supratek Pharma (Canada); Institut National de la Recherche Scientifique","funders":"National Science Foundation","keywords":"Poloxamer; Chemistry; Gene delivery; Nuclease; Transfection; Transgene; In vivo; Excipient; In vitro; Molecular biology; DNA; Genetic enhancement; Biophysics; Cell biology; Plasmid; Gene; Copolymer; Biochemistry; Chromatography; Polymer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003807345,0.0005126052,0.0004103063,0.0003761666,0.0002119256,0.0004377221,0.0003273651,0.0004408878,0.0007524549],"category_scores_gemma":[0.0003401513,0.000317517,0.0002663359,0.0003049015,0.0002231707,0.0004013366,0.0002067049,0.0005828261,0.0005634208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000555405,"about_ca_system_score_gemma":0.0003900647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000495045,"about_ca_topic_score_gemma":0.0007126569,"domain_scores_codex":[0.9998166,0.00002784934,0.00002854032,0.00004920665,0.00005177021,0.00002611607],"domain_scores_gemma":[0.9998442,0.0000286332,0.0000508758,0.000009456655,0.00003539875,0.00003144103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007268106,0.00004145853,0.00007106914,0.0000946674,0.000009260139,0.00007203365,0.00003131446,0.0007845344,0.9947408,0.0002816162,0.00005473002,0.003745872],"study_design_scores_gemma":[0.00002783362,0.0003427941,0.0002661835,0.000004750758,0.00001667235,0.0001068071,0.000005935798,0.002381492,0.9932894,0.00004327961,0.003503226,0.00001164084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9188437,0.003244198,0.07316228,0.0002064185,0.000119407,0.00119324,0.0003960509,0.0003787804,0.002455868],"genre_scores_gemma":[0.8914009,0.003034668,0.09662292,0.00012594,0.00004280276,0.0009302065,0.0005393116,0.0001202959,0.007182953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007524549,"threshold_uncertainty_score":0.00402981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411697598743899,"score_gpt":0.232817588442043,"score_spread":0.208700612454604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}