{"id":"W2096924058","doi":"10.1111/j.1755-5949.2010.00146.x","title":"Relevance of Norepinephrine–Dopamine Interactions in the Treatment of Major Depressive Disorder","year":2010,"lang":"en","type":"review","venue":"CNS Neuroscience & Therapeutics","topic":"Treatment of Major Depression","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Ottawa Mental Health Centre; Children’s Health Research Institute; University of Ottawa","funders":"","keywords":"Monoaminergic; Neurochemical; Neuroscience; Norepinephrine; Dopamine; Dopaminergic; Monoamine neurotransmitter; Major depressive disorder; Psychology; Serotonergic; Serotonin; Pharmacology; Medicine; Internal medicine; Amygdala; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003553454,0.0004720953,0.00087881,0.0009200234,0.0001877283,0.0003862582,0.0004879843,0.0006218911,0.002385581],"category_scores_gemma":[0.0002972497,0.0001606901,0.000247718,0.001060488,0.0002233682,0.000365982,0.00027979,0.0009049648,0.001843085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003653623,"about_ca_system_score_gemma":0.0006383881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001227337,"about_ca_topic_score_gemma":0.003137802,"domain_scores_codex":[0.9998902,0.0000272724,0.00001556811,0.00001635645,0.00004213001,0.000008510702],"domain_scores_gemma":[0.9999006,0.0000419194,0.00001677992,0.000003022336,0.00002688681,0.00001077528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005975801,0.00008175113,0.0001785262,0.008041968,0.00007396652,0.0002026268,0.00005163759,0.000293085,0.00282684,0.001825881,0.01299926,0.9733646],"study_design_scores_gemma":[0.0000589662,0.0002448794,0.003531605,0.003825075,0.0001460193,0.002223981,0.00008668174,0.0001669799,0.001087548,0.001914505,0.9866953,0.0000184618],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003115461,0.9972447,0.0001246045,0.0002556505,0.0001215061,0.000008112199,0.00001363534,0.000005830002,0.001914432],"genre_scores_gemma":[0.001735381,0.9968266,0.0003087952,0.0001961401,0.0001043343,0.000007577097,0.00002188399,0.000001142615,0.0007981009],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002385581,"threshold_uncertainty_score":0.007980585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09039054354524115,"score_gpt":0.3924868266784436,"score_spread":0.3020962831332025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}