{"id":"W2096942508","doi":"10.1007/978-3-7643-8238-4_12","title":"Perspectives in targeted therapy","year":2009,"lang":"en","type":"book-chapter","venue":"Birkhäuser Basel eBooks","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Rheumatoid arthritis; Targeted therapy; Clinical trial; Adverse effect; Disease; Pharmacodynamics; Intensive care medicine; Bioinformatics; Immunology; Pharmacology; Internal medicine; Cancer; Pharmacokinetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002539978,0.0005004447,0.0007788386,0.0006384725,0.000082201,0.00005189622,0.0001936563,0.0003894953,0.001893761],"category_scores_gemma":[0.00004171282,0.0004328706,0.0003084071,0.00002985993,0.0002566556,0.00005227112,0.00003865579,0.0008633533,0.000293562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001541151,"about_ca_system_score_gemma":0.0004019007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000651127,"about_ca_topic_score_gemma":0.00009924093,"domain_scores_codex":[0.9977913,0.00004613238,0.0004312551,0.0006088401,0.000600432,0.0005219614],"domain_scores_gemma":[0.998738,0.00007139624,0.0001104044,0.0006206513,0.0001873235,0.0002722254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003148851,0.0004675836,0.0005072557,0.0001175544,0.0008384088,0.002524953,0.00712795,7.433853e-7,0.003838846,0.2284059,0.01193267,0.7410893],"study_design_scores_gemma":[0.00581826,0.001209264,0.002453625,0.001303529,0.00000933858,0.0001241511,0.000294067,0.0000145111,0.001005157,0.03304016,0.9539797,0.0007482243],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.004832156,0.04235969,0.000006645812,0.000699511,0.00008146725,0.001184701,0.00004002174,0.0002169311,0.9505789],"genre_scores_gemma":[0.07693696,0.0413746,0.0004301647,0.0008750204,0.0003415277,0.00005971591,0.00007428534,0.000204325,0.8797034],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.9420471,"threshold_uncertainty_score":0.9998123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03429795942491473,"score_gpt":0.2781819587194271,"score_spread":0.2438839992945124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}