{"id":"W2097018673","doi":"10.1002/chem.200801578","title":"Total Syntheses of Casuarine and Its 6‐<i>O</i>‐α‐Glucoside: Complementary Inhibition towards Glycoside Hydrolases of the GH31 and GH37 Families","year":2009,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; Biotechnology and Biological Sciences Research Council; Ministero dell’Istruzione, dell’Università e della Ricerca; Ente Cassa di Risparmio di Firenze","keywords":"Glucoside; Glycoside hydrolase; Trehalase; Stereochemistry; Enzyme; Stereoselectivity; Chemistry; Cycloaddition; Glycoside; Nitrone; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001787393,0.0001086207,0.0001124161,0.00001542825,0.00008817035,0.00001944652,0.00007355034,0.00002477815,0.00003438942],"category_scores_gemma":[0.0001116394,0.00008592074,0.00004829976,0.00004720197,0.0000858095,0.00001073181,0.0000845389,0.0001013792,2.096471e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005625802,"about_ca_system_score_gemma":0.00002448694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000140602,"about_ca_topic_score_gemma":2.920554e-7,"domain_scores_codex":[0.9992996,0.00007499677,0.0002688748,0.0001524197,0.0001073498,0.00009677222],"domain_scores_gemma":[0.9995106,0.000005430745,0.0002095328,0.0001269183,0.0000910919,0.00005637536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005742904,0.00004385994,0.0004320466,0.00005142574,0.00002031798,0.000003212208,0.00006725106,0.00001142206,0.9959959,0.000003017173,0.0001634421,0.003150625],"study_design_scores_gemma":[0.0003597697,0.0001079316,0.01718507,0.00008648142,0.00002595654,0.0006641483,0.0001454448,0.00005791419,0.9803253,0.000009765004,0.000944723,0.00008749295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979389,0.0007430621,0.00003310379,0.0004486285,0.00004287109,0.00005088944,0.00003000046,0.000004161208,0.0007083928],"genre_scores_gemma":[0.9987378,0.0007068747,0.00007435057,0.0001177584,0.0001966143,4.424057e-7,0.00002809162,0.000009806693,0.0001282611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01675302,"threshold_uncertainty_score":0.3503746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126679893742916,"score_gpt":0.2157898204139954,"score_spread":0.2045230214765663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}