{"id":"W2097018673","doi":"10.1002/chem.200801578","title":"Total Syntheses of Casuarine and Its 6‐<i>O</i>‐α‐Glucoside: Complementary Inhibition towards Glycoside Hydrolases of the GH31 and GH37 Families","year":2009,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; Biotechnology and Biological Sciences Research Council; Ministero dell’Istruzione, dell’Università e della Ricerca; Ente Cassa di Risparmio di Firenze","keywords":"Glucoside; Glycoside hydrolase; Trehalase; Stereochemistry; Enzyme; Stereoselectivity; Chemistry; Cycloaddition; Glycoside; Nitrone; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001432255,0.0008085839,0.0003606609,0.0003710898,0.0002263698,0.0003030011,0.0003897749,0.0002943722,0.001303017],"category_scores_gemma":[0.0001793076,0.0001529199,0.0003790038,0.0004177797,0.0002010095,0.0003201462,0.000288305,0.000528621,0.0005790088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003711147,"about_ca_system_score_gemma":0.0005343008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001001696,"about_ca_topic_score_gemma":0.001725401,"domain_scores_codex":[0.9998583,0.00002100595,0.00001238195,0.00003355451,0.00003630631,0.00003843607],"domain_scores_gemma":[0.9998661,0.00001501023,0.00002771089,0.00002494526,0.00002932609,0.00003693057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009220839,0.00002361366,0.00004824824,0.0001316158,0.00001404421,0.0001019165,0.00004582193,0.0002932739,0.9939224,0.0004303051,0.00008951175,0.004807101],"study_design_scores_gemma":[0.000009595197,0.0002126966,0.0002950866,0.000005941685,0.00001546804,0.00008912328,0.00001226753,0.0002502899,0.9945931,0.00006745353,0.004439996,0.000009050858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9296092,0.004892785,0.03665034,0.0001751044,0.000111688,0.0002409218,0.003165763,0.0005478836,0.02460617],"genre_scores_gemma":[0.9647124,0.003366982,0.02279062,0.00006661623,0.00002100509,0.0001365112,0.002088292,0.0001595601,0.006657937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303017,"threshold_uncertainty_score":0.004359007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126679893742916,"score_gpt":0.2157898204139954,"score_spread":0.2045230214765663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}