{"id":"W2097061706","doi":"10.1172/jci15748","title":"Increased ABCA1 activity protects against atherosclerosis","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":250,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia; BC Children's Hospital; Xenon Pharmaceuticals (Canada); Children's & Women's Health Centre of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Efflux; Cholesterol; Reverse cholesterol transport; Apolipoprotein E; Genetically modified mouse; Phospholipid; Transgene; Endocrinology; Chemistry; In vivo; Transporter; Internal medicine; Biology; Lipoprotein; Biochemistry; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003009017,0.0004037863,0.0009730741,0.000385809,0.0001943908,0.0004446211,0.0002891016,0.0004943567,0.003240131],"category_scores_gemma":[0.0003411565,0.0002310811,0.0002656471,0.0002247564,0.0002997618,0.0002586512,0.0002641827,0.001489785,0.0007612613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001788971,"about_ca_system_score_gemma":0.0002190083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003688767,"about_ca_topic_score_gemma":0.0003391732,"domain_scores_codex":[0.9997802,0.00005209147,0.00002080717,0.00002928849,0.00004336868,0.00007410232],"domain_scores_gemma":[0.9996253,0.00004234108,0.00007302876,0.00007871735,0.00004731975,0.0001332363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004056202,0.001134145,0.00109704,0.0001413381,0.00009324469,0.0001758639,0.00003027691,0.0001196773,0.9727963,0.0003658722,0.000955041,0.01903499],"study_design_scores_gemma":[0.002427511,0.03248163,0.05936618,0.0001049169,0.0005810097,0.002350578,0.0001491036,0.001878715,0.8778213,0.001120399,0.02165809,0.000060575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919153,0.004245081,0.0008728858,0.0005115353,0.0001584573,0.00002354361,0.0002617441,0.0002723656,0.001739008],"genre_scores_gemma":[0.9930128,0.002286078,0.0004458581,0.0002255525,0.00010099,0.00003450735,0.0006615717,0.00003013312,0.003202594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003240131,"threshold_uncertainty_score":0.01083934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1444098704158182,"score_gpt":0.3598064876084234,"score_spread":0.2153966171926052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}