{"id":"W2097062325","doi":"10.1093/protein/14.5.367","title":"Investigation of the `switch-epitope' concept with random peptide libraries displayed as thioredoxin loop fusions","year":2001,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Epitope; Peptide; Chemistry; Affinity chromatography; Epitope mapping; Thioredoxin; Avidity; Monoclonal antibody; Biochemistry; Polyclonal antibodies; Linear epitope; Histidine; Molecular biology; Biotinylation; Antibody; Mutagenesis; Peptide sequence; Biology; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003095333,0.0003515235,0.0002532141,0.0001659253,0.0000935093,0.0004946999,0.0003433196,0.0002555175,0.000522918],"category_scores_gemma":[0.0002917222,0.0001362844,0.0001698849,0.0001766796,0.0001631754,0.000269502,0.0002566984,0.0003554623,0.0002404922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002131079,"about_ca_system_score_gemma":0.0001141762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001684499,"about_ca_topic_score_gemma":0.0002357102,"domain_scores_codex":[0.9997591,0.0000499598,0.0000108909,0.00004034779,0.00007916064,0.00006053883],"domain_scores_gemma":[0.9998719,0.00003579744,0.00003082182,0.00001226895,0.00002181671,0.00002742008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006726732,0.00007243359,0.0001271789,0.00003396468,0.00000844566,0.00006867476,0.00001405195,0.0003453635,0.9955167,0.000171349,0.0000309333,0.003543562],"study_design_scores_gemma":[0.00002756877,0.0006558837,0.0008312278,0.000004460551,0.00001868351,0.0003930595,0.00001722934,0.002171817,0.9937179,0.00006027225,0.002095914,0.000005907873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857627,0.0006333061,0.01208834,0.00005708726,0.00001252043,0.00009801418,0.0001098751,0.00009872988,0.001139396],"genre_scores_gemma":[0.9811215,0.0008081725,0.01576549,0.00009182074,0.000009784811,0.00006790729,0.0004368433,0.0000321188,0.00166627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000522918,"threshold_uncertainty_score":0.001749337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556555080674281,"score_gpt":0.2227313100949582,"score_spread":0.2071657592882154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}